ArticleScientific reports2014
In vivo flow mapping in complex vessel networks by single image correlation.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Laser speckle contrast imaging of hepatic microcirculation.Biomedical optics express · 2025Article
- Measuring capillary flow dynamics using interlaced two-photon volumetric scanning.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Abnormally primed CD8 T cells: The Achilles' heel of CHB.Frontiers in immunology · 2023Review
- Immunobiology and pathogenesis of hepatitis B virus infection.Nature reviews. Immunology · 2022Review
- Formula feeding and immature gut microcirculation promote intestinal hypoxia, leading to necrotizing enterocolitis.Disease models & mechanisms · 2019Article
- Dynamics and genomic landscape of CD8Nature · 2019Article
- A simple automated method for continuous fieldwise measurement of microvascular hemodynamics.Microvascular research · 2019Article
- Adaptive optics microspectrometer for cross-correlation measurement of microfluidic flows.Journal of biomedical optics · 2019Article
- MicroTools enables automated quantification of capillary density and red blood cell velocity in handheld vital microscopy.Communications biology · 2019Article
- Out of the Randomness: Correlating Noise in Biological Systems.Biophysical journal · 2018Review
- The three Rs: Recruitment, Retention and Residence of leukocytes in the liver.Clinical & translational immunology · 2016Review
- Spatiotemporal dynamics of effector CD8+ T cell responses within the liver.Journal of leukocyte biology · 2016Review
- Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
We describe a novel method (FLICS, FLow Image Correlation Spectroscopy) to extract flow speeds in complex vessel networks from a single raster-scanned optical xy-image, acquired in vivo by confocal or two-photon excitation microscopy. Fluorescent flowing objects produce diagonal lines in the raster-scanned image superimposed to static morphological details. The flow velocity is obtained by computing the Cross Correlation Function (CCF) of the intensity fluctuations detected in pairs of columns of the image. The analytical expression of the CCF has been derived by applying scanning fluorescence correlation concepts to drifting optically resolved objects and the theoretical framework has been validated in systems of increasing complexity. The power of the technique is revealed by its application to the intricate murine hepatic microcirculatory system where blood flow speed has been mapped simultaneously in several capillaries from a single xy-image and followed in time at high spatial and temporal resolution.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.