Evidence map›Paper›PMID 25475103›Full record

ReviewGut2015

MicroRNAs: new players in IBD.

R Kalla, N T Ventham, N A Kennedy, J F Quintana, E R Nimmo, A H Buck, J Satsangi

Erratum issuedAbstract readReview
In one paragraph

Review in Gut, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 148 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
148citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

148 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
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  5. AXL-dependent autophagy impairment differentiates monocyte-derived macrophages from Crohn's disease and intestinal tuberculosis.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026
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  18. Article
  19. Relationship between peripheral bloodFrontiers in immunology · 2025
    Article
  20. Article

88 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

R KallaGastrointestinal Unit, Centre for Molecular Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK.
N T VenthamGastrointestinal Unit, Centre for Molecular Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK.
N A KennedyGastrointestinal Unit, Centre for Molecular Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK.
J F QuintanaCentre for Immunity, Infection and Evolution, Ashworth laboratories, University of Edinburgh, Edinburgh, UK.
E R NimmoGastrointestinal Unit, Centre for Molecular Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK.
A H BuckCentre for Immunity, Infection and Evolution, Ashworth laboratories, University of Edinburgh, Edinburgh, UK.
J SatsangiGastrointestinal Unit, Centre for Molecular Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK.

Funding

Chief Scientist Office CZB/4/540Chief Scientist Office ETM/137Chief Scientist Office ETM/75Medical Research Council G0800675Medical Research Council G0800759Wellcome Trust 095831Wellcome Trust 097943
6 · The paper itself

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs, 18-23 nucleotides long, which act as post-transcriptional regulators of gene expression. miRNAs are strongly implicated in the pathogenesis of many common diseases, including IBDs. This review aims to outline the history, biogenesis and regulation of miRNAs. The role of miRNAs in the development and regulation of the innate and adaptive immune system is discussed, with a particular focus on mechanisms pertinent to IBD and the potential translational applications.

Indexed as

Adaptive ImmunityEpigenesis, GeneticGenetic MarkersHumansImmunity, InnateInflammatory Bowel DiseasesMicroRNAsGenetic MarkersMicroRNAsCELLULAR IMMUNOLOGYCROHN'S DISEASEINTESTINAL TRACTT LYMPHOCYTESULCERATIVE COLITIS

Identifiers

PMID25475103
PMCPMC4345829

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.