ArticlePLoS neglected tropical diseases2014
Glucose- but not rice-based oral rehydration therapy enhances the production of virulence determinants in the human pathogen Vibrio cholerae.
Article in PLoS neglected tropical diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 46 citations in OpenAlex.
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- Epidemicity conditions in spatial models of infectious diseases.Bollettino della Unione matematica italiana (2008) · 2026Article
- Structural insight intoActa biochimica et biophysica Sinica · 2025Article
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- Informing policy via dynamic models: Cholera in Haiti.PLoS computational biology · 2024Article
- Rise of cholera in Iraq: A rising concern.Annals of medicine and surgery (2012) · 2022Article
- Sewage Promotes Vibrio vulnificus Growth and Alters Gene Transcription in Vibrio vulnificus CMCP6.Microbiology spectrum · 2022Article
- Effects of intestinal microbiota on physiological metabolism and pathogenicity ofFrontiers in microbiology · 2022Review
- Modulation of quorum sensing-associated virulence in bacteria: carbohydrate as a key factor.Archives of microbiology · 2021Review
- Aerobic Metabolism in Vibrio cholerae Is Required for Population Expansion during Infection.mBio · 2020Article
- A MARTX ToxinmBio · 2020Article
- Ecological implications of gene regulation by TfoX and TfoY among diverse Vibrio species.Environmental microbiology · 2019Article
- Conditions for transient epidemics of waterborne disease in spatially explicit systems.Royal Society open science · 2019Article
- Combating Cholera.F1000Research · 2019Review
- cAMP Receptor Protein Controls Vibrio cholerae Gene Expression in Response to Host Colonization.mBio · 2018Article
- Glucose-Specific Enzyme IIA of the Phosphoenolpyruvate:Carbohydrate Phosphotransferase System Modulates Chitin Signaling Pathways in Vibrio cholerae.Journal of bacteriology · 2017Article
- Mobile phone data highlights the role of mass gatherings in the spreading of cholera outbreaks.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
Despite major attempts to prevent cholera transmission, millions of people worldwide still must address this devastating disease. Cholera research has so far mainly focused on the causative agent, the bacterium Vibrio cholerae, or on disease treatment, but rarely were results from both fields interconnected. Indeed, the treatment of this severe diarrheal disease is mostly accomplished by oral rehydration therapy (ORT), whereby water and electrolytes are replenished. Commonly distributed oral rehydration salts also contain glucose. Here, we analyzed the effects of glucose and alternative carbon sources on the production of virulence determinants in the causative agent of cholera, the bacterium Vibrio cholerae during in vitro experimentation. We demonstrate that virulence gene expression and the production of cholera toxin are enhanced in the presence of glucose or similarly transported sugars in a ToxR-, TcpP- and ToxT-dependent manner. The virulence genes were significantly less expressed if alternative non-PTS carbon sources, including rice-based starch, were utilized. Notably, even though glucose-based ORT is commonly used, field studies indicated that rice-based ORT performs better. We therefore used a spatially explicit epidemiological model to demonstrate that the better performing rice-based ORT could have a significant impact on epidemic progression based on the recent outbreak of cholera in Haiti. Our results strongly support a change of carbon source for the treatment of cholera, especially in epidemic settings.
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