Trial reportAnnals of the American Thoracic Society2015
Chest computed tomography predicts the frequency of pulmonary exacerbations in children with cystic fibrosis.
Trial report in Annals of the American Thoracic Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 6 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- State-of-the-art review of lung imaging in cystic fibrosis with recommendations for pulmonologists and radiologists from the "iMAging managEment of cySTic fibROsis" (MAESTRO) consortium.European respiratory review : an official journal of the European Respiratory Society · 2022Pooled it
- Dornase alfa for cystic fibrosis.The Cochrane database of systematic reviews · 2021Pooled it
- Timing of dornase alfa inhalation for cystic fibrosis.The Cochrane database of systematic reviews · 2021Pooled it
- Timing of dornase alfa inhalation for cystic fibrosis.The Cochrane database of systematic reviews · 2018Pooled it
- Dornase alfa for cystic fibrosis.The Cochrane database of systematic reviews · 2018Pooled it
- Timing of dornase alfa inhalation for cystic fibrosis.The Cochrane database of systematic reviews · 2016Pooled it
- Quantitative chest computerized tomography and FEVPediatric pulmonology · 2018Trial
- Short-term monitoring of CFTR modulator therapy in adults and children with cystic fibrosis using low and ultra-low-dose lung CT.La Radiologia medica · 2026Article
- Pseudomonas infections persisting after CFTR modulators are widespread throughout the lungs and drive lung inflammation.Cell host & microbe · 2025Article
- The Impact of Highly Effective Modulator Therapy on Cystic Fibrosis Microbiology and Inflammation.Clinics in chest medicine · 2022Review
- Sensitive structural and functional measurements and 1-year pulmonary outcomes in pediatric cystic fibrosis.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2021Article
- Predictive value of the modified Bhalla score for assessment of pulmonary exacerbations in adults with cystic fibrosis.European radiology · 2021Article
- [Cystic fibrosis and computed tomography of the lungs].Der Radiologe · 2020Review
- Predictive value of computed tomography scoring systems evolution in adults with cystic fibrosis.European radiology · 2020Article
- CT score and correlation with lung function and microbiology of adult patients with cystic fibrosis with predominant I1234V genotype in Qatar.Qatar medical journal · 2020Article
- Airway disease on chest computed tomography of preschool children with cystic fibrosis is associated with school-age bronchiectasis.Pediatric pulmonology · 2020Article
- The value of high-resolution computed tomography (HRCT) to determine exercise ventilatory inefficiency and dynamic hyperinflation in adult patients with cystic fibrosis.Respiratory research · 2019Article
- Pathogenesis, imaging and clinical characteristics of CF and non-CF bronchiectasis.BMC pulmonary medicine · 2018Review
- A semiquantitative MRI-Score can predict loss of lung function in patients with cystic fibrosis: Preliminary results.European radiology · 2018Article
- Treatment and demographic factors affecting time to next pulmonary exacerbation in cystic fibrosis.Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
rationaleAbnormalities on chest computed tomography (CT) in children with cystic fibrosis (CF) have been shown to correlate with short-term measures of lung disease. Chest CT scores offer promise as a potential surrogate end point in CF; however, there is limited information available on the ability of chest CT scores to predict future morbidity.
objectivesDetermine whether chest CT scores are associated with the rate of pulmonary exacerbations over the next 10 years.
methodsTen years of follow-up data were obtained from the CF Foundation Patient Registry for 60 children enrolled in the Pulmozyme Early Intervention Trial and who had chest CT scans at baseline. MEASUREMENTS AND MAIN
resultsMultivariable Poisson regression was used to compare Brody CT scores and the number of pulmonary exacerbations in the following 10 years. At the time of the chest CT, the mean (SD) age was 10.6 (1.7) years. A 1-point increase in the Brody CT score was associated with an increase in the mean (95% confidence interval) rate of pulmonary exacerbations of 1.39 (1.15, 1.67) (P < 0.001). Brody CT scores were more strongly associated with the number of pulmonary exacerbations than FEV1 % predicted at the time of the chest CT (P = 0.037 by chi-square test).
conclusionsThere is a significant association between Brody CT scores and the rate of pulmonary exacerbations up to 10 years later. This association is stronger than for FEV1 obtained at the time of the CT, suggesting that chest CT scores offer improved ability to predict future outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.