ArticleeLife2014
Homeostasis in C. elegans sleep is characterized by two behaviorally and genetically distinct mechanisms.
Article in eLife, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- Waking Up the Sleep Field: An Overview on the Implications of Genetics and Bioinformatics of Sleep.Molecular biotechnology · 2024Review
- New alleles ofmicroPublication biology · 2024Article
- Inhibitory feedback from the motor circuit gates mechanosensory processing in Caenorhabditis elegans.PLoS biology · 2023Article
- A sleep-active neuron can promote survival while sleep behavior is disturbed.PLoS genetics · 2023Article
- G protein-coupled receptor kinase-2 (GRK-2) controls exploration through neuropeptide signaling in Caenorhabditis elegans.PLoS genetics · 2023Article
- Article
- Intracellular CaiScience · 2022Article
- Synaptic dysfunction connects autism spectrum disorder and sleep disturbances: A perspective from studies in model organisms.Sleep medicine reviews · 2022Review
- Co-transmission of neuropeptides and monoamines choreograph the C. elegans escape response.PLoS genetics · 2022Article
- Sleep Analysis in AdultThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Regulation of Satiety Quiescence by Neuropeptide Signaling inFrontiers in neuroscience · 2021Article
- Article
- Behavioral States.Genetics · 2020Review
- RPamide neuropeptides NLP-22 and NLP-2 act through GnRH-like receptors to promote sleep and wakefulness in C. elegans.Scientific reports · 2020Article
- A quiescent state following mild sensory arousal in Caenorhabditis elegans is potentiated by stress.Scientific reports · 2020Article
- A wake-active locomotion circuit depolarizes a sleep-active neuron to switch on sleep.PLoS biology · 2020Article
- Forward genetic approach for behavioral neuroscience using animal models.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2020Article
- A microfluidic-induced C. elegans sleep state.Nature communications · 2019Article
- Interneurons Regulate Locomotion Quiescence via Cyclic Adenosine Monophosphate Signaling During Stress-Induced Sleep inGenetics · 2019Article
- Exploring phylogeny to find the function of sleep.Nature reviews. Neuroscience · 2019Review
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Authors and funding
7 authors.
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Abstract
Biological homeostasis invokes modulatory responses aimed at stabilizing internal conditions. Using tunable photo- and mechano-stimulation, we identified two distinct categories of homeostatic responses during the sleep-like state of Caenorhabditis elegans (lethargus). In the presence of weak or no stimuli, extended motion caused a subsequent extension of quiescence. The neuropeptide Y receptor homolog, NPR-1, and an inhibitory neuropeptide known to activate it, FLP-18, were required for this process. In the presence of strong stimuli, the correlations between motion and quiescence were disrupted for several minutes but homeostasis manifested as an overall elevation of the time spent in quiescence. This response to strong stimuli required the function of the DAF-16/FOXO transcription factor in neurons, but not that of NPR-1. Conversely, response to weak stimuli did not require the function of DAF-16/FOXO. These findings suggest that routine homeostatic stabilization of sleep may be distinct from homeostatic compensation following a strong disturbance.
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