Evidence map›Paper›PMID 25474017›Full record

ReviewCurrent opinion in clinical nutrition and metabolic care2015

Bolus vs. continuous feeding to optimize anabolism in neonates.

Teresa A Davis, Marta L Fiorotto, Agus Suryawan

Registry-linked trialAbstract readComparative StudyReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current opinion in clinical nutrition and metabolic care, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06721923 (Continuous Versus Bolus Dietary Protein and Nutrition Status in the Pediatric Intensive Care Unit), which is not on this map. Cited by 18 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 3 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06721923 narecruitingnot on this mapstarted 2024, after this paper: background citation

Continuous Versus Bolus Dietary Protein and Nutrition Status in the Pediatric Intensive Care Unit: Pilot Study

TypeinterventionalSponsorUniversity of British ColumbiaRan2024 to 2027Enrolled96ConditionsCritical Illness, Pediatric Intensive Care, Enteral Nutrition Therapy, Dietary ProteinArmsDietary protein
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 37 citations in OpenAlex.

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  16. Mechanisms of protein balance in skeletal muscle.Domestic animal endocrinology · 2016
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Teresa A DavisDepartment of Pediatrics, USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, Houston, Texas, USA.
Marta L Fiorotto
Agus Suryawan
Children's Nutrition Research Center at Baylor College of Medicine · USBaylor College of Medicine · US

Funding

Regulation of Neonatal Muscle Protein SynthesisR01AR044474 · NIAMS · BAYLOR COLLEGE OF MEDICINE · PI DAVIS, TERESA A · 1996 to 2012
$4.2M
DEVELOPMENTAL DETERMINANTS OF SKELETAL MUSCLE GROWTH POTENTIALR01AR046308 · NIAMS · BAYLOR COLLEGE OF MEDICINE · PI FIOROTTO, MARTA L · 2000 to 2011
$2.9M
Leucine Supplementation to Promote Lean Growth in Early LifeR01HD072891 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI DAVIS, TERESA A · 2012 to 2015
$1.4M
DEVELOPMENTAL DETERMINANTS OF SKELETAL MUSCLE GROWTHR55AR046308 · NIAMS · BAYLOR COLLEGE OF MEDICINE · PI FIOROTTO, MARTA L · 1999 to 1999
–
NIAMS NIH HHS AR-044474NIAMS NIH HHS AR-46308NIAMS NIH HHS R01 AR044474NIAMS NIH HHS R01 AR046308NIAMS NIH HHS R55 AR046308NICHD NIH HHS HD-072891NICHD NIH HHS R01 HD072891
6 · The paper itself

Abstract

purpose of reviewNeonates with feeding difficulties can be fed by orogastric tube, using either continuous or bolus delivery. This review reports on recent findings that bolus is advantageous compared to continuous feeding in supporting optimal protein anabolism. RECENT

findingsWhether bolus or continuous feeding is more beneficial has been controversial, largely due to limitations inherent in clinical studies, such as the presence of confounding variables and the inability to use invasive approaches. Recent studies using the piglet as a model of the human neonate showed that, compared to continuous feeding, bolus feeding enhances protein synthesis and promotes greater protein deposition. The increase in protein synthesis occurs in muscles of varying fiber type and in visceral tissues whereas muscle protein degradation is largely insensitive to feeding pattern. This higher protein synthesis rate is enabled by the rapid and profound increases in circulating amino acids and insulin that occur following a bolus feed, which activate the intracellular signaling pathways leading to mRNA translation. SUMMARY: Recent findings indicate that bolus feeding enhances protein synthesis more than continuous feeding and promotes greater protein anabolism. The difference in response is attributable to the pulsatile pattern of amino acid-induced and insulin-induced translation initiation induced only by bolus feeding.

Indexed as

Feeding MethodsGrowthInfant Nutritional Physiological PhenomenaProtein BiosynthesisAmino AcidsAnimalsHumansInfant, NewbornInsulinMuscle ProteinsMuscle, SkeletalAmino AcidsInsulinMuscle Proteins

Identifiers

PMID25474017
PMCPMC4409765
OpenAlexW2313024252

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.