ArticleNature medicine2014
IL-18 is not therapeutic for neovascular age-related macular degeneration.
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Article in Nature medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24citing papers in PubMed
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Who cites it
24 citing papers in PubMed.
- The role of NLRP3 inflammasome in age-related macular degeneration: mechanisms and therapeutic prospects.Frontiers in aging neuroscience · 2026Review
- Natural active ingredients targeted inflammatory cytokines and major blinding eye diseases: a two-sample Mendelian randomization and molecular docking analysis.Frontiers in medicine · 2025Article
- Inflammasome activation aggravates choroidal neovascularization.Angiogenesis · 2024Article
- The contribution of pattern recognition receptor signalling in the development of age related macular degeneration: the role of toll-like-receptors and the NLRP3-inflammasome.Journal of neuroinflammation · 2024Review
- Distinct effects of complement and of NLRP3- and non-NLRP3 inflammasomes for choroidal neovascularization.eLife · 2020Article
- Epigenetics in age-related macular degeneration: new discoveries and future perspectives.Cellular and molecular life sciences : CMLS · 2020Review
- An in vitro model of chronic wounding and its implication for age-related macular degeneration.PloS one · 2020Article
- IL-1 Family Members Mediate Cell Death, Inflammation and Angiogenesis in Retinal Degenerative Diseases.Frontiers in immunology · 2019Review
- Inflammasomes, the eye and anti-inflammasome therapy.Eye (London, England) · 2018Review
- Evidence for the activation of pyroptotic and apoptotic pathways in RPE cells associated with NLRP3 inflammasome in the rodent eye.Journal of neuroinflammation · 2018Article
- cGAS drives noncanonical-inflammasome activation in age-related macular degeneration.Nature medicine · 2018Article
- Article
- THE PATHOPHYSIOLOGY OF GEOGRAPHIC ATROPHY SECONDARY TO AGE-RELATED MACULAR DEGENERATION AND THE COMPLEMENT PATHWAY AS A THERAPEUTIC TARGET.Retina (Philadelphia, Pa.) · 2017Review
- Chronic, Systemic Interleukin-18 Does Not Promote Macular Degeneration or Choroidal Neovascularization.Investigative ophthalmology & visual science · 2017Article
- Diverse roles of macrophages in intraocular neovascular diseases: a review.International journal of ophthalmology · 2017Review
- Inflammation and its role in age-related macular degeneration.Cellular and molecular life sciences : CMLS · 2016Review
- Nucleoside Reverse Transcriptase Inhibitors Suppress Laser-Induced Choroidal Neovascularization in Mice.Investigative ophthalmology & visual science · 2015Article
- Inflammasomes Induced by 7-Ketocholesterol and Other Stimuli in RPE and in Bone Marrow-Derived Cells Differ Markedly in Their Production of IL-1β and IL-18.Investigative ophthalmology & visual science · 2015Article
- Inflammatory Mechanisms of Age-related Macular Degeneration.International ophthalmology clinics · 2015Review
- Reply to IL-18 is not therapeutic for neovascular age-related macular degeneration.Nature medicine · 2014Article
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Authors and funding
24 authors.
Yoshio HiranoDepartment of Ophthalmology and Visual Sciences, University of Kentucky, Lexington, Kentucky, USA.
Tetsuhiro YasumaDepartment of Ophthalmology and Visual Sciences, University of Kentucky, Lexington, Kentucky, USA.
Takeshi MizutaniDepartment of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Benjamin J FowlerDepartment of Ophthalmology and Visual Sciences, University of Kentucky, Lexington, Kentucky, USA.
Valeria Tarallo1] Department of Ophthalmology and Visual Sciences, University of Kentucky, Lexington, Kentucky, USA. [2] Institute of Genetics and Biophysics Adriano Buzzati-Traverso, Consiglio Nazionale delle Ricerche (CNR), Naples, Italy.
Reo YasumaDepartment of Ophthalmology and Visual Sciences, University of Kentucky, Lexington, Kentucky, USA.
Younghee KimDepartment of Ophthalmology and Visual Sciences, University of Kentucky, Lexington, Kentucky, USA.
Ana Bastos-CarvalhoDepartment of Ophthalmology and Visual Sciences, University of Kentucky, Lexington, Kentucky, USA.
Nagaraj KerurDepartment of Ophthalmology and Visual Sciences, University of Kentucky, Lexington, Kentucky, USA.
Bradley D Gelfand1] Department of Ophthalmology and Visual Sciences, University of Kentucky, Lexington, Kentucky, USA. [2] Department of Biomedical Engineering, University of Kentucky, Lexington, Kentucky, USA. [3] Department of Microbiology, Immunology and Human Genetics, University of Kentucky, Lexington, Kentucky, USA.
Sasha BogdanovichDepartment of Ophthalmology and Visual Sciences, University of Kentucky, Lexington, Kentucky, USA.
Shikun He1] Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA. [2] Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.
Xiaohui ZhangDepartment of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Miho NozakiDepartment of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Ryo IjimaDepartment of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Hiroki KanekoDepartment of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Yuichiro OguraDepartment of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Hiroko TerasakiDepartment of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Hiroshi NagaiDivision of Dermatology, Kobe University School of Medicine, Chuo-ku, Kobe, Japan.
Isao HaroDepartment of Urology, Wakayama Medical University, Wakayama, Japan.
Gabriel NúñezDepartment of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Balamurali K Ambati1] Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah, USA. [2] Department of Ophthalmology, Veterans Affairs Salt Lake City Healthcare System, Salt Lake City, Utah, USA.
David R Hinton1] Department of Pathology, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA. [2] Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA.
Jayakrishna Ambati1] Department of Ophthalmology and Visual Sciences, University of Kentucky, Lexington, Kentucky, USA. [2] Department of Physiology, University of Kentucky, Lexington, Kentucky, USA.
Funding
Kentucky Center for Clinical and Translational ScienceUL1TR000117 · NCATS · UNIVERSITY OF KENTUCKY · PI KERN, PHILIP A · 2012 to 2015
$13.3MVISION RESEARCHP30EY003040 · NEI · DOHENY EYE INSTITUTE · PI SUN, DEMING · 1985 to 2013
$7.0MEXPERIMENTAL APPROACH TO MACULOPATHYR01EY001545 · NEI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HINTON, DAVID R. · 1985 to 2016
$6.0MThe Role of Soluble Flt-1 and Raver2 in Ocular Vascular DemarcationsR01EY017950 · NEI · UNIVERSITY OF UTAH · PI AMBATI, BALAMURALI K · 2008 to 2021
$5.2MForm and function of our Janus faced genomeDP1GM114862 · NIGMS · UNIVERSITY OF VIRGINIA · PI AMBATI, JAYAKRISHNA · 2014 to 2018
$4.0MIntraceptor Interference of VEGF PathwaysR01EY017182 · NEI · UNIVERSITY OF UTAH · PI AMBATI, BALAMURALI K · 2007 to 2017
$3.6MKENTUCKY CENTER FOR CLINICAL AND TRANSLATIONAL SCIENCEUL1RR033173 · NCRR · UNIVERSITY OF KENTUCKY · PI KERN, PHILIP A · 2011 to 2011
$3.5MFunctional studies of DICER1 and Alu RNA in geographic atrophyR01EY022238 · NEI · UNIVERSITY OF VIRGINIA · PI AMBATI, JAYAKRISHNA · 2012 to 2016
$3.3MCryopyrin Signaling in Inflammation and Innate ImmunityR01AI063331 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NUNEZ, GABRIEL · 2005 to 2015
$3.3MInflammasome Activation in Geographic AtrophyR01EY024068 · NEI · UNIVERSITY OF VIRGINIA · PI AMBATI, JAYAKRISHNA · 2014 to 2017
$2.6MClinical Scholars In Cardiovascular ScienceT32HL091812 · NHLBI · UNIVERSITY OF KENTUCKY · PI SMYTH, SUSAN S. · 2008 to 2018
$2.3MPro-and anti-angiogenic effects of vascular endothelial growth factor-AR01EY018350 · NEI · UNIVERSITY OF KENTUCKY · PI AMBATI, JAYAKRISHNA · 2007 to 2011
$1.9MNCATS NIH HHS TL1 TR000115NCATS NIH HHS UL1 TR000117NCCDPHP CDC HHS DP1GM114862NCRR NIH HHS TL1 RR033172NCRR NIH HHS UL1 RR033173NCRR NIH HHS UL1RR033173NEI NIH HHS K99 EY024336NEI NIH HHS K99EY024336NEI NIH HHS P30 EY003040NEI NIH HHS P30EY003040NEI NIH HHS R01 EY001545NEI NIH HHS R01EY001545NEI NIH HHS R01 EY017182NEI NIH HHS R01EY017182NEI NIH HHS R01 EY017950NEI NIH HHS R01EY017950NEI NIH HHS R01 EY018350NEI NIH HHS R01EY018350NEI NIH HHS R01 EY018836NEI NIH HHS R01EY018836NEI NIH HHS R01 EY020672NEI NIH HHS R01EY020672NEI NIH HHS R01 EY022238NEI NIH HHS R01EY022238NEI NIH HHS R01 EY024068NHLBI NIH HHS T32 HL091812NHLBI NIH HHS T32HL091812NIAID NIH HHS R01 AI063331NIAID NIH HHS R01AI063331NIAMS NIH HHS R01 AR052756NIAMS NIH HHS R01AR052756NIGMS NIH HHS DP1 GM114862
Abstract
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Indexed as
AnimalsChoroidal NeovascularizationHumansInterleukin-18Macular DegenerationInterleukin-18
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