ArticleFunctional neurology
Cortical spreading depression: origins and paths as inferred from the sequence of events during migraine aura.
Article in Functional neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Dysphasia and Other Higher Cortical Dysfunctions During the Migraine Aura-a Systematic Review of Literature.Current pain and headache reports · 2020Pooled it
- Comparison of the Effect of Tanacethum Parthenium, 5-Hydroxy Tryptophan, and Magnesium (Aurastop) versus Magnesium Alone on Aura Phenomenon and Its Evolution.Pain research & management · 2019Trial
- Sex-dependent cognitive and behavioral outcomes induced by repetitive cortical spreading depression in mice.The journal of headache and pain · 2026Article
- Pediatric Migraine Aura Status and Cortical Laminar Necrosis: A Clinical Case and a Narrative Review.Revista de neurologia · 2026Review
- Progesterone receptors regulate susceptibility to spreading depression.Experimental neurology · 2025Article
- Behavioral and Cognitive Consequences of Spreading Depolarizations: A Translational Scoping Review.Journal of neurotrauma · 2025Article
- Subsegmentation of the hippocampus in subgroups of migraine with aura patients: advanced structural neuroimaging study.The journal of headache and pain · 2024Article
- Article
- Cortical spreading depolarization-induced constriction of penetrating arteries can cause watershed ischemia: A potential mechanism for white matter lesions.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Excitation-Inhibition Imbalance in Migraine: From Neurotransmitters to Brain Oscillations.International journal of molecular sciences · 2023Review
- Visual Disturbances Spectrum in Pediatric Migraine.Journal of clinical medicine · 2023Review
- Study on "Atypical" Migraine Auras in the Pediatric Age: The Role of Cortical Spreading Depression and the Physiopathogenetic Hypothesis Arising from Our Clinical Cases.Life (Basel, Switzerland) · 2022Article
- Functional connectivity changes in complex migraine aura: beyond the visual network.European journal of neurology · 2022Article
- Aura Mapping: Where Vision and Somatosensation Meet.Vision (Basel, Switzerland) · 2021Article
- Imaging Neurovascular Uncoupling in Acute Migraine with Aura with Susceptibility Weighted Imaging.Clinical neuroradiology · 2021Article
- Headache Medicine Grand Challenge: Headache: A New Frontier, A New Challenge.Frontiers in pain research (Lausanne, Switzerland) · 2021Article
- Neuropeptide changes in an improved migraine model with repeat stimulations.Translational neuroscience · 2021Article
- Application of the Migraine Aura Complexity Score (MACS): Clinical and Neuroimaging Study.Frontiers in neurology · 2019Article
- Stereological Analysis of Early Gene Expression Using Egr-1 Immunolabeling After Spreading Depression in the Rat Somatosensory Cortex.Frontiers in neuroscience · 2019Article
- Interictal brain activity differs in migraine with and without aura: resting state fMRI study.The journal of headache and pain · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Patients with migraine with aura often experience a variety of visual and somatosensory phenomena and disturbances of higher cortical functions. Analysis of these alterations may provide important information about the involvement of different cortical regions in cortical spreading depression (CSD). We report five cases of migraineurs who experience unusually abundant clinical phenomena during auras. These patients were selected from a cohort of migraine with aura patients who were interviewed, using a specially designed questionnaire, to evaluate the presence of higher cortical dysfunctions. On the basis of the aura symptoms they reported, we attempted to infer the origin and the possible paths of CSD in each patient. According to their reported symptoms, CSD could begin in the primary visual cortex, in the primary somatosensory cortex or simultaneously in both, and propagate to the posterior parietal cortex, the temporal lobe and Broca's area. We believe that clinical descriptions of aura could play an important role in further investigations of the pathophysiology of migraine.
Indexed as
Identifiers
25473742PMC4264789W2259793190What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.