ArticleMolecular cancer biology2013
Women with endometriosis have a higher DNA repair capacity and diminished breast cancer risk.
Article in Molecular cancer biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- The association between endometriosis and risk of endometrial cancer and breast cancer: a meta-analysis.BMC women's health · 2022Pooled it
- Breast Cancer in Patients with Previous Endometriosis Showed Low Aggressive Subtype.Medicina (Kaunas, Lithuania) · 2024Article
- Causal effects of genetically predicted endometriosis on breast cancer: a two-sample Mendelian randomization study.Scientific reports · 2023Article
- Association between breast diseases and symptomatic uterine fibroids by using South Korean National Health Insurance database.Scientific reports · 2023Article
- Genetic Contribution of Endometriosis to the Risk of Developing Hormone-Related Cancers.International journal of molecular sciences · 2021Article
- Cancer driver mutations in endometriosis: Variations on the major theme of fibrogenesis.Reproductive medicine and biology · 2018Review
- Laparoscopically Confirmed Endometriosis and Breast Cancer in the Nurses' Health Study II.Obstetrics and gynecology · 2016Article
- A prospective study of endometriosis and risk of benign breast disease.Breast cancer research and treatment · 2016Article
- Endometriosis and mammographic density measurements in the Nurses' Health Study II.Cancer causes & control : CCC · 2016Article
- Endometriosis and breast cancer: A survey of the epidemiological studies.Oncology letters · 2016Article
- Endometriosis: a high-risk population for major chronic diseases?Human reproduction updateReview
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
introductionBreast cancer (BC) and endometriosis are important reproductive health diseases for women. Although endometriosis is not a malignant condition, some of its characteristics mimic that of a malignancy. Endometriosis is associated with increased risk of certain cancers; however, whether it alters BC risk is unclear. This study evaluates the association of endometriosis and BC and explores whether DNA repair capacity (DRC) plays a role in such a relationship. MATERIALS AND
methodsA case-control study of 991 women (385 with BC and 606 controls, all recruited over 5 years) was undertaken in Puerto Rico. Eighty participants with self-reported surgically diagnosed endometriosis were identified, 20 of whom also had a diagnosis of BC. Data from a structured questionnaire and DRC measurements were assessed to determine the association between BC, DRC, and endometriosis.
resultsParticipants with BC cases were 50% less likely to have history of endometriosis (OR = 0.5 95%CI: 0.3, 0.9, DISCUSSION: Here we report an inverse association between endometriosis and BC, the former possibly conferring a protective effect on the latter. Although the mechanisms involved are unknown they may include protection provided by higher DRC and or hormonal treatments for endometriosis. A larger sample of endometriosis cases is necessary to confirm these results and answer the question of whether a higher DRC capacity may contribute to this potential protection, and to identify other factors at play.
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