Evidence map›Paper›PMID 25473442›Full record

ReviewInternational journal of stem cells2014

The molecular nature of very small embryonic-like stem cells in adult tissues.

YongHwan Kim, Jaeho Jeong, Hyunsook Kang, Jisun Lim, Jinbeom Heo, Janina Ratajczak, Mariusz Z Ratajczak, Dong-Myung Shin

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of stem cells, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
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  11. Review
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  13. Of Cytometry, Stem Cells and Fountain of Youth.Stem cell reviews and reports · 2017
    Review
  14. Article
  15. Review
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

YongHwan KimDepartment of Biomedical Sciences, University of Ulsan College of Medicine, Seoul, Korea ; Department of Physiology, University of Ulsan College of Medicine, Seoul, Korea.
Jaeho JeongDepartment of Biomedical Sciences, University of Ulsan College of Medicine, Seoul, Korea ; Department of Physiology, University of Ulsan College of Medicine, Seoul, Korea.
Hyunsook KangDepartment of Biomedical Sciences, University of Ulsan College of Medicine, Seoul, Korea ; Department of Physiology, University of Ulsan College of Medicine, Seoul, Korea.
Jisun LimDepartment of Biomedical Sciences, University of Ulsan College of Medicine, Seoul, Korea ; Department of Physiology, University of Ulsan College of Medicine, Seoul, Korea.
Jinbeom HeoDepartment of Biomedical Sciences, University of Ulsan College of Medicine, Seoul, Korea ; Department of Physiology, University of Ulsan College of Medicine, Seoul, Korea.
Janina RatajczakStem Cell Institute at the James Graham Brown Cancer Center, University of Louisville, KY, USA.
Mariusz Z RatajczakStem Cell Institute at the James Graham Brown Cancer Center, University of Louisville, KY, USA.
Dong-Myung ShinDepartment of Biomedical Sciences, University of Ulsan College of Medicine, Seoul, Korea ; Department of Physiology, University of Ulsan College of Medicine, Seoul, Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pluripotent stem cells (PSCs) have been considered as the most important cells in regenerative medicine as they are able to differentiate into all types of cells in the human body. PSCs have been established from several sources of embryo tissue or by reprogramming of terminally differentiated adult tissue by transduction of so-called Yamanaka factors (Oct4, Sox2, Klf4, and cMyc). Interestingly, accumulating evidence has demonstrated the residence of PSCs in adult tissue and with the ability to differentiate into multiple types of tissue-committed stem cells (TCSCs). We also recently demonstrated that a population of pluripotent Oct4(+) SSEA-1(+)Sca-1(+)Lin(-)CD45(-) very small embryonic-like stem cells (VSELs) resides in the adult murine bone marrow (BM) and in other murine tissue. These very small (∼3-6 μm) cells express pluripotent markers such as Oct4, Nanog, and SSEA-1. VSELs could be specified into several tissue-residing TCSCs in response to tissue/organ injury, and thus suggesting that these cells have a physiological role in the rejuvenation of a pool of TCSCs under steady-state conditions. In this review article, we discuss the molecular nature of the rare population of VSELs which have a crucial role in regulating the pluripotency, proliferation, differentiation, and aging of these cells.

Indexed as

DNA MethylationGenomic ImprintingPGCPluripotencyVSEL

Identifiers

PMID25473442
PMCPMC4249904

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.