Evidence map›Paper›PMID 25473375›Full record

ArticleTropical medicine and health2014

Pilot Study on Interferon-γ-producing T Cell Subsets after the Protective Vaccination with Radiation-attenuated Cercaria of Schistosoma japonicum in the Miniature Pig Model.

Ekhlas Hamed Abdel-Hafeez, Kanji Watanabe, Kaori Kamei, Mihoko Kikuchi, Honggen Chen, Boamah Daniel, Chuanxin Yu, Kenji Hirayama

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tropical medicine and health, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Schistosome Vaccines for Domestic Animals.Tropical medicine and infectious disease · 2018
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 3 countries.

Ekhlas Hamed Abdel-HafeezDepartment of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Nagasaki University , 1-14-2 Sakamoto, Nagasaki 852-8523, Japan ; Department of Parasitology, Faculty of Medicine, Minia University , Minia, 61519, Egypt.
Kanji WatanabeDepartment of Parasitology, Institute of Tropical Medicine (NEKKEN), Nagasaki University , 1-14-2 Sakamoto, Nagasaki 852-8523, Japan.
Kaori KameiDepartment of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Nagasaki University , 1-14-2 Sakamoto, Nagasaki 852-8523, Japan.
Mihoko KikuchiDepartment of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Nagasaki University , 1-14-2 Sakamoto, Nagasaki 852-8523, Japan.
Honggen ChenJiangxi Provintial Institute of Parasitic Diseases , Nanchang 330046, P.R. China.
Boamah DanielDepartment of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Nagasaki University , 1-14-2 Sakamoto, Nagasaki 852-8523, Japan.
Chuanxin YuJiangsu Institute of Parasitic Diseases , Wuxi, Jiangsu 214064, P.R. China.
Kenji HirayamaDepartment of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Nagasaki University , 1-14-2 Sakamoto, Nagasaki 852-8523, Japan.
Nagasaki University · JPJiangsu Institute of Parasitic Diseases · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CLAWN miniature pig has been shown to serve as a suitable host for the experimental infection of Schistosoma japonicum. In this study, we found that radiation-attenuated cercaria (RAC) vaccine gave CLAWN miniature pigs protective immunity against subsequent challenge infection with S. japonicum cercaria. To characterize the protective immune response of the pig model vaccinated by attenuated cercaria, flow cytometric analysis of the reactive T cell subsets was performed. The intracellular interferon (IFN)-γ and the cell surface markers revealed the peripheral blood CD3+ T-lymphocytes produced significant amounts of IFN-γ during the immunization period and after the challenge infection. CD4+ αβ-T cells as well as CD4+/CD8α(mid) double positive and/or CD8α(high) αβ-T cells were the major IFN-γ-producing CD3+ T cells. On the contrary, γδ T cells did not produce intracellular IFN-γ. Our results suggested that RAC-vaccinated miniature pigs showed effective protective immunity through the activation of αβ T cells bearing antigen specific T-cell receptors but not through the activation of γδ T cells.

Indexed as

IFN-γminiature pigradiation attenuated cercariaSchistosoma japonicumVaccineαβ T cell receptorγδ T cells

Identifiers

PMID25473375
PMCPMC4219940
OpenAlexW2135672086

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.