ArticleInternational journal of nanomedicine2014
Cytotoxicity and antibacterial activity of gold-supported cerium oxide nanoparticles.
Article in International journal of nanomedicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 95 citations in OpenAlex.
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- Exploration of Cytotoxicity and Antibacterial Activities of M-CeoChemistryOpen · 2025Article
- A potential strategy against clinical carbapenem-resistant Enterobacteriaceae: antimicrobial activity study of sweetener-decorated gold nanoparticles in vitro and in vivo.Journal of nanobiotechnology · 2023Article
- Plant Gel-Mediated Synthesis of Gold-Coated Nanoceria UsingJournal of functional biomaterials · 2023Article
- Selective laser welding in liquid: A strategy for preparation of high-antibacterial activity nanozyme against Staphylococcus aureus.Journal of advanced research · 2023Article
- Gold Nanoparticles Supported on Ceria Nanoparticles Modulate Leukocyte-Endothelium Cell Interactions and Inflammation in Type 2 Diabetes.Antioxidants (Basel, Switzerland) · 2022Article
- Recent Research on Hybrid Hydrogels for Infection Treatment and Bone Repair.Gels (Basel, Switzerland) · 2022Review
- Cerium oxide nanostructures: properties, biomedical applications and surface coatings.3 Biotech · 2022Review
- The Use of Cerium Compounds as Antimicrobials for Biomedical Applications.Molecules (Basel, Switzerland) · 2022Review
- Comparable Studies on Nanoscale Antibacterial Polymer Coatings Based on Different Coating Procedures.Nanomaterials (Basel, Switzerland) · 2022Article
- Graphene nanoplatelets/CeOApplied nanoscience · 2022Article
- On Placental Toxicology Studies and Cerium Dioxide Nanoparticles.International journal of molecular sciences · 2021Review
- Interrelationships between the structural, spectroscopic, and antibacterial properties of nanoscale (< 50 nm) cerium oxides.Scientific reports · 2021Article
- Alteration of the Mitochondrial Effects of Ceria Nanoparticles by Gold: An Approach for the Mitochondrial Modulation of Cells Based on Nanomedicine.Nanomaterials (Basel, Switzerland) · 2020Article
- Potential applications and human biosafety of nanomaterials used in nanomedicine.Journal of applied toxicology : JAT · 2018Review
- pH-Controlled Cerium Oxide Nanoparticle Inhibition of Both Gram-Positive and Gram-Negative Bacteria Growth.Scientific reports · 2017Article
- Article
- Cerium oxide nanoparticles inhibit the migration and proliferation of gastric cancer by increasing DHX15 expression.International journal of nanomedicine · 2016Article
- Cerium oxide nanoparticle treatment ameliorates peritonitis-induced diaphragm dysfunction.International journal of nanomedicine · 2015Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCerium oxide nanoparticles (CeO2) have been shown to be a novel therapeutic in many biomedical applications. Gold (Au) nanoparticles have also attracted widespread interest due to their chemical stability and unique optical properties. Thus, decorating Au on CeO2 nanoparticles would have potential for exploitation in the biomedical field.
methodsIn the present work, CeO2 nanoparticles synthesized by a chemical combustion method were supported with 3.5% Au (Au/CeO2) by a deposition-precipitation method. The as-synthesized Au, CeO2, and Au/CeO2 nanoparticles were evaluated for antibacterial activity and cytotoxicity in RAW 264.7 normal cells and A549 lung cancer cells.
resultsThe as-synthesized nanoparticles were characterized by X-ray diffraction, scanning and transmission electron microscopy, and ultraviolet-visible measurements. The X-ray diffraction study confirmed the formation of cubic fluorite-structured CeO2 nanoparticles with a size of 10 nm. All synthesized nanoparticles were nontoxic towards RAW 264.7 cells at doses of 0-1,000 μM except for Au at >100 μM. For A549 cancer cells, Au/CeO2 had the highest inhibitory effect, followed by both Au and CeO2 which showed a similar effect at 500 and 1,000 μM. Initial binding of nanoparticles occurred through localized positively charged sites in A549 cells as shown by a shift in zeta potential from positive to negative after 24 hours of incubation. A dose-dependent elevation in reactive oxygen species indicated that the pro-oxidant activity of the nanoparticles was responsible for their cytotoxicity towards A549 cells. In addition, cellular uptake seen on transmission electron microscopic images indicated predominant localization of nanoparticles in the cytoplasmic matrix and mitochondrial damage due to oxidative stress. With regard to antibacterial activity, both types of nanoparticles had the strongest inhibitory effect on Bacillus subtilis in monoculture systems, followed by Salmonella enteritidis, Escherichia coli, and Staphylococcus aureus, while, in coculture tests with Lactobacillus plantarum, S. aureus was inhibited to a greater extent than the other bacteria.
conclusionGold-supported CeO2 nanoparticles may be a potential nanomaterial for in vivo application owing to their biocompatible and antibacterial properties.
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