ArticleAnnals of dermatology2014
The effect of evening primrose oil for the prevention of xerotic cheilitis in acne patients being treated with isotretinoin: a pilot study.
Article in Annals of dermatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- Exposome involvement in the development of acne vulgaris.Frontiers in immunology · 2026Review
- Use of Oral Supplements and Topical Adjuvants for Isotretinoin-Associated Side Effects: A Narrative Review.Skin appendage disorders · 2024Review
- Lip Mesotherapy with Dexpanthenol as a Novel Approach to Prevent Isotretinoin-Associated Cheilitis.Dermatology practical & conceptual · 2023Article
- Oxidative Stability and Protective Effect of the Mixture betweenPlants (Basel, Switzerland) · 2022Article
- Diet and Skin Barrier: The Role of Dietary Interventions on Skin Barrier Function.Dermatology practical & conceptual · 2021Review
- Omega-3 Versus Omega-6 Polyunsaturated Fatty Acids in the Prevention and Treatment of Inflammatory Skin Diseases.International journal of molecular sciences · 2020Review
- Evening Primrose (Antioxidants (Basel, Switzerland) · 2018Review
- Oral Isotretinoin May Improve the Symptoms of Chronic Rhinosinusitis.Journal of clinical and diagnostic research : JCDR · 2017Article
- Objective assessment of isotretinoin-associated cheilitis: Isotretinoin Cheilitis Grading Scale.The Journal of dermatological treatment · 2016Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe most common adverse effects of oral isotretinoin are cheilitis, skin dryness, dry eyes, and conjunctivitis, whereas evening primrose oil (EPO) is known to improve skin moisture and transepidermal water loss (TEWL) in healthy adults and atopic patients.
objectiveTo evaluate the clinical efficacy and safety of EPO in preventing xerotic cheilitis in acne patients being treated with oral isotretinoin.
methodsForty Korean volunteers of Fitzpatrick skin types III and IV, having moderate acne, were enrolled and randomized to receive either isotretinoin with or without EPO for 8 weeks. The efficacy of treatment was evaluated on the basis of global acne grading system scores, number of inflammatory and noninflammatory lesions, TEWL, corneometry, physician's global assessment, and patient satisfaction.
resultsThe results after 8 weeks of treatment showed that the TEWL of the lip increased significantly during isotretinoin treatment, whereas the TEWL of the hand dorsum showed no significant change. The increase of the TEWL of the lip was more definite in the control group than in the experimental group. The number of acne lesions decreased significantly in both groups, and there were no differences between them.
conclusionOur study suggests that the addition of EPO improved xerotic cheilitis in acne patients being treated with oral isotretinoin. However, besides TEWL and corneometry assessments, additional studies are required for a complete understanding of the role of EPO in xerotic cheilitis in acne patients being treated with oral isotretinoin.
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