Evidence map›Paper›PMID 25473182›Full record

ArticleWorld journal of gastroenterology2014

Insulin-like growth factor receptor-1 overexpression is associated with poor response of rectal cancers to radiotherapy.

Xiao-Yu Wu, Zhen-Feng Wu, Qin-Hong Cao, Che Chen, Zhi-Wei Chen, Zhe Xu, Wei-Su Li, Fu-Kun Liu, Xue-Quan Yao, Gang Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Radiotherapy resistance: identifying universal biomarkers for various human cancers.Journal of cancer research and clinical oncology · 2022
    Review
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiao-Yu WuXiao-Yu Wu, Zhen-Feng Wu, Qin-Hong Cao, Che Chen, Zhi-Wei Chen, Zhe Xu, Wei-Su Li, Fu-Kun Liu, Xue-Quan Yao, Department of Surgical Oncology, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing 210029, Jiangsu Province, China.
Zhen-Feng WuXiao-Yu Wu, Zhen-Feng Wu, Qin-Hong Cao, Che Chen, Zhi-Wei Chen, Zhe Xu, Wei-Su Li, Fu-Kun Liu, Xue-Quan Yao, Department of Surgical Oncology, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing 210029, Jiangsu Province, China.
Qin-Hong CaoXiao-Yu Wu, Zhen-Feng Wu, Qin-Hong Cao, Che Chen, Zhi-Wei Chen, Zhe Xu, Wei-Su Li, Fu-Kun Liu, Xue-Quan Yao, Department of Surgical Oncology, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing 210029, Jiangsu Province, China.
Che ChenXiao-Yu Wu, Zhen-Feng Wu, Qin-Hong Cao, Che Chen, Zhi-Wei Chen, Zhe Xu, Wei-Su Li, Fu-Kun Liu, Xue-Quan Yao, Department of Surgical Oncology, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing 210029, Jiangsu Province, China.
Zhi-Wei ChenXiao-Yu Wu, Zhen-Feng Wu, Qin-Hong Cao, Che Chen, Zhi-Wei Chen, Zhe Xu, Wei-Su Li, Fu-Kun Liu, Xue-Quan Yao, Department of Surgical Oncology, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing 210029, Jiangsu Province, China.
Zhe XuXiao-Yu Wu, Zhen-Feng Wu, Qin-Hong Cao, Che Chen, Zhi-Wei Chen, Zhe Xu, Wei-Su Li, Fu-Kun Liu, Xue-Quan Yao, Department of Surgical Oncology, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing 210029, Jiangsu Province, China.
Wei-Su LiXiao-Yu Wu, Zhen-Feng Wu, Qin-Hong Cao, Che Chen, Zhi-Wei Chen, Zhe Xu, Wei-Su Li, Fu-Kun Liu, Xue-Quan Yao, Department of Surgical Oncology, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing 210029, Jiangsu Province, China.
Fu-Kun LiuXiao-Yu Wu, Zhen-Feng Wu, Qin-Hong Cao, Che Chen, Zhi-Wei Chen, Zhe Xu, Wei-Su Li, Fu-Kun Liu, Xue-Quan Yao, Department of Surgical Oncology, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing 210029, Jiangsu Province, China.
Xue-Quan YaoXiao-Yu Wu, Zhen-Feng Wu, Qin-Hong Cao, Che Chen, Zhi-Wei Chen, Zhe Xu, Wei-Su Li, Fu-Kun Liu, Xue-Quan Yao, Department of Surgical Oncology, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing 210029, Jiangsu Province, China.
Gang LiXiao-Yu Wu, Zhen-Feng Wu, Qin-Hong Cao, Che Chen, Zhi-Wei Chen, Zhe Xu, Wei-Su Li, Fu-Kun Liu, Xue-Quan Yao, Department of Surgical Oncology, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing 210029, Jiangsu Province, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo explore the potential correlation between insulin-like growth factor receptor-1 (IGF-1R) expression and rectal cancer radiosensitivity.

methodsEighty-seven rectal cancer patients (cTNM I-III) treated in our department between January 2011 and December 2012 were enrolled. All subjects were treated with preoperative radiotherapy and radical resection of rectal carcinoma. Immunohistochemistry and reverse transcription polymerase chain reaction (RT-PCR) were performed to detect IGF-1R expression in pre-treatment and postoperative colorectal cancer specimens. Radiosensitivity for rectal cancer specimens was evaluated by observing rectal carcinoma mass regression combined with fibrosis on HE staining, degree of necrosis and quantity of remaining tumor cells. The relative IGF-1R expression was evaluated for association with tumor radiosensitivity.

resultsImmunohistochemistry showed diffuse IGF-1R staining on rectal cancer cells with various degrees of signal density. IGF-1R expression was significantly correlated with cTNM staging (P = 0.012) while no significant association was observed with age, sex, tumor size and degree of differentiation (P = 0.424, 0.969, 0.604, 0.642). According to the Rectal Cancer Regression Grades (RCRG), there were 31 cases of RCRG1 (radiation sensitive), 28 cases of RCRG2 and 28 cases of RCRG3 (radiation resistance) in 87 rectal cancer subjects. IGF-1R protein hyper-expression was significantly correlated with a poor response to radiotherapy (P < 0.001, r = 0.401). RT-PCR results from pre-radiation biopsy specimens also showed that IGF-1R mRNA negative group exhibited a higher radiation sensitivity (P < 0.001, r = 0.497). Compared with the pre-radiation biopsy specimens, the paired post-operative specimens showed a significantly increased IGF-1R protein and mRNA expression in the residual cancer cells (P < 0.001, respectively).

conclusionIGF-1R expression level may serve as a predictive biomarker for radiosensitivity of rectal cancer before preoperative radiotherapy.

Indexed as

Neoadjuvant TherapyRadiotherapy, Intensity-ModulatedBiomarkers, TumorBiopsyCarcinomaFemaleFibrosisHumansImmunohistochemistryMaleMiddle AgedNecrosisNeoplasm StagingRadiation ToleranceRadiotherapy, AdjuvantReceptor, IGF Type 1Biomarkers, TumorIGF1R protein, humanReceptor, IGF Type 1Receptors, SomatomedinRNA, MessengerImmunohistochemistryInsulin-like growth factor-1 receptorPreoperative radiotherapyRectal carcinomaReverse transcription-polymerase chain reaction

Identifiers

PMID25473182
PMCPMC4239516

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.