Evidence map›Paper›PMID 25473149›Full record

ReviewWorld journal of gastroenterology2014

Histopathology of hepatocellular carcinoma.

Manuel Schlageter, Luigi Maria Terracciano, Salvatore D'Angelo, Paolo Sorrentino

Abstract readReview
In one paragraph

Review in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 113 papers.

0numbers the graph read from it
0cells of the map it votes in
113citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

113 citing papers in PubMed.

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53 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Manuel SchlageterManuel Schlageter, Luigi Maria Terracciano, Department of Pathology, University Hospital Basel, 4031 Basel, Switzerland.
Luigi Maria TerraccianoManuel Schlageter, Luigi Maria Terracciano, Department of Pathology, University Hospital Basel, 4031 Basel, Switzerland.
Salvatore D'AngeloManuel Schlageter, Luigi Maria Terracciano, Department of Pathology, University Hospital Basel, 4031 Basel, Switzerland.
Paolo SorrentinoManuel Schlageter, Luigi Maria Terracciano, Department of Pathology, University Hospital Basel, 4031 Basel, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is currently the sixth most common type of cancer with a high mortality rate and an increasing incidence worldwide. Its etiology is usually linked to environmental, dietary or life-style factors. HCC most commonly arises in a cirrhotic liver but interestingly an increasing proportion of HCCs develop in the non-fibrotic or minimal fibrotic liver and a shift in the underlying etiology can be observed. Although this process is yet to be completely understood, this changing scenario also has impact on the material seen by pathologists, presenting them with new diagnostic dilemmas. Histopathologic criteria for diagnosing classical, progressed HCC are well established and known, but with an increase in detection of small and early HCCs due to routine screening programs, the diagnosis of these small lesions in core needle biopsies poses a difficult challenge. These lesions can be far more difficult to distinguish from one another than progressed HCC, which is usually a clear cut hematoxylin and eosin diagnosis. Furthermore lesions thought to derive from progenitor cells have recently been reclassified in the WHO. This review summarizes recent developments and tries to put new HCC biomarkers in context with the WHOs reclassification. Furthermore it also addresses the group of tumors known as combined hepatocellular-cholangiocellular carcinomas.

Indexed as

AnimalsBile Duct NeoplasmsBile Ducts, IntrahepaticBiomarkers, TumorBiopsyCarcinoma, HepatocellularCholangiocarcinomaDiagnosis, DifferentialHumansImmunohistochemistryLiver NeoplasmsNeoplasm GradingNeoplasms, Complex and MixedPrecancerous ConditionsPredictive Value of TestsBiomarkers, TumorHepatocellular carinomaHistologyPathology

Identifiers

PMID25473149
PMCPMC4239483

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.