ArticleMolecular biology of the cell2015
Single-cell variation leads to population invariance in NF-κB signaling dynamics.
Article in Molecular biology of the cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- Macrophage response specificity to ligand mixtures is improved by signaling pathway antagonism.Molecular systems biology · 2026Article
- Heritable single-cell gene expression states shape functional variability in innate immune responses.bioRxiv : the preprint server for biology · 2026Article
- Heterogeneous NF-κB activation and enhancer features shape transcription in Drosophila immunity.Biophysical journal · 2026Article
- Autonomous Oscillations of NF-κB.Advances in experimental medicine and biology · 2026Review
- Heterogeneous NF-κB activation and enhancer features shape transcription inbioRxiv : the preprint server for biology · 2025Article
- Co-imaging of RelA and c-Rel reveals features of NF-κB signaling for ligand discrimination.Cell reports · 2024Article
- Evidence of collective influence in innate sensing using fluidic force microscopy.Frontiers in immunology · 2024Article
- Myddosome clustering in IL-1 receptor signaling regulates the formation of an NF-kB activating signalosome.EMBO reports · 2023Article
- Droplet microarray platforms for high-throughput drug screening.Mikrochimica acta · 2023Review
- Modulation of transcription factor dynamics allows versatile information transmission.Scientific reports · 2023Article
- Insights on the NF-κB System Using Live Cell Imaging: Recent Developments and Future Perspectives.Frontiers in immunology · 2022Review
- Review
- A forecast for large-scale, predictive biology: Lessons from meteorology.Cell systems · 2021Review
- Six distinct NFκB signaling codons convey discrete information to distinguish stimuli and enable appropriate macrophage responses.Immunity · 2021Article
- Epigenetically regulated digital signaling defines epithelial innate immunity at the tissue level.Nature communications · 2021Article
- Information transmission from NFkB signaling dynamics to gene expression.PLoS computational biology · 2020Article
- Dual Feedforward Loops Modulate Type I Interferon Responses and Induce Selective Gene Expression during TLR4 Activation.iScience · 2020Article
- Macrophages employ quorum licensing to regulate collective activation.Nature communications · 2020Article
- What Will B Will B: Identifying Molecular Determinants of Diverse B-Cell Fate Decisions Through Systems Biology.Frontiers in cell and developmental biology · 2020Review
- Stimulus-specificity in the Responses of Immune Sentinel Cells.Current opinion in systems biology · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The activation dynamics of nuclear factor (NF)-κB have been shown to affect downstream gene expression. On activation, NF-κB shuttles back and forth across the nuclear envelope. Many dynamic features of this shuttling have been characterized, and most features vary significantly with respect to ligand type and concentration. Here, we report an invariant feature with regard to NF-κB dynamics in cellular populations: the distribution--the average, as well as the variance--of the time between two nuclear entries (the period). We find that this period is conserved, regardless of concentration and across several different ligands. Intriguingly, the distributions observed at the population level are not observed in individual cells over 20-h time courses. Instead, the average period of NF-κB nuclear translocation varies considerably among single cells, and the variance is much smaller within a cell than that of the population. Finally, analysis of daughter-cell pairs and isogenic populations indicates that the dynamics of the NF-κB response is heritable but diverges over multiple divisions, on the time scale of weeks to months. These observations are contrary to the existing theory of NF-κB dynamics and suggest an additional level of control that regulates the overall distribution of translocation timing at the population level.
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Registered trials
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