ReviewScience translational medicine2014
Wound repair and regeneration: mechanisms, signaling, and translation.
Review in Science translational medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 7 registered trials, which are not on this map. Cited by 1,507 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early Healing of Oral Soft Tissues: a Clinical and Biomolecular Analysis Part I - Gene Expression and Cellular Behaviour 24-hours After Injury
Early Healing of Oral Soft Tissues: a Clinical and Biomolecular Analysis. Part II - Effect of Local Chlorhexidine Administration in Gene Expression and Cellular Behaviour 24-hours After Injury
Effect of Hyaluronic Acid Application in Gene Expression and Cellular Behavior 24-hours After Injury
Open, Non-comparative, Multicentre Clinical Investigation to Evaluate the Performance and Safety of the Medical Device Plenhyage® (Polymerised Polynucleotides Dermal Filler) in the Treatment of Dermal Tissue Defects
Open, Non-comparative, Multicentre Clinical Investigation to Evaluate the Performance and Safety of the Medical Device Auralya® (Hyaluronic Acid-dermal Filler) in the Treatment of Facial Dermal Tissue Defects
Open, Non-comparative, Multicentre Clinical Investigation to Evaluate the Performance and Safety of the Medical Device Janesse® (Hyaluronic Acid-dermal Filler) in the Treatment of Facial Dermal Tissue Defects
Open, Non-comparative, Multicentre Clinical Investigation to Evaluate the Performance and Safety of the Medical Device Jalucomplex® (Hyaluronic Acid-dermal Filler) in the Treatment of Facial and Neck Dermal Tissue Defects
Who cites it
1,507 citing papers in PubMed.
- A First-In-Human Randomized Controlled Phase 1 Study Assessing the Safety and Tolerability of Topical TCP-25 Gel in Epidermal Suction Blister Wounds.Clinical and translational science · 2026Trial
- A spatiotemporally programmed bioactive scaffold for orbital reconstruction.Bioactive materials · 2027Article
- Engineering bioactive citrate-based hydrogels for wound repair: From structure-function design to microenvironmental regulation.Bioactive materials · 2027Review
- Zinc silicate microspheres-mediated bacterial metabolic interference and microenvironment remodeling for chronic wound repair.Bioactive materials · 2027Article
- An injectable hydrogel for localized sustained release of artesunate in postoperative fibrosis prevention after glaucoma filtration surgery.Drug delivery · 2026Article
- Article
- Systematic engineering of Layer-by-Layer anti-miR coated wound dressings with tunable release kinetics.Biomaterials advances · 2026Article
- Exploring the efficacy of antimicrobial photodynamic therapy (aPDT) with magnetic fields (MFs) stimulation in treating methicillin-resistant Staphylococcus aureus (MRSA) infected wounds in rats using 532 and 660 nm laser.Lasers in medical science · 2026Article
- Assessment of the Wound-Healing Properties of Almond Oil in a Murine Excisional Wound Model: Biochemical Mechanisms and Translational Perspectives.ACS pharmacology & translational science · 2026Article
- Review
- Mechanistic Evaluation of Luteolin in Wound Healing of Diabetic Foot Ulcer via Nrf2 Signaling.Phytotherapy research : PTR · 2026Article
- Compartment-specific Zinc Misallocation in Diabetic Foot Ulcers: Mechanistic Coupling Between Macrophage M1 Locking and MMP-9 Hyperactivation.Biological trace element research · 2026Review
- Bioactive Compound-Integrated Metal Nanoparticles Promote Wound Repair in Diabetic Conditions: Evidence from an Animal Study.Applied biochemistry and biotechnology · 2026Review
- Targeting the neuro-immune-skin axis: Advanced functional biomaterials for intelligent wound management and regeneration.Materials today. Bio · 2026Review
- The Interplay of M1 Macrophages and Dental Pulp Stem Cells Promotes Angiogenesis Through IL-8-Dependent VEGF Regulation: An In Vitro Study.International endodontic journal · 2026Article
- A Bioactive 3D-Bioprinted AuNC@DHLA/GelMA Hydrogel Containing Skin Cells Promotes Burn Wound Healing and Tissue Regeneration.Polymers · 2026Article
- Injectable Thermoresponsive Hydrogels for Antibacterial Applications: Design Strategies, Antibacterial Mechanisms, and Biomedical Applications.Materials (Basel, Switzerland) · 2026Review
- Dual-Component Nanoemulsion ContainingPlants (Basel, Switzerland) · 2026Article
- Inflammasome-derived biomarkers in wound healing: linking tissue repair, chronic inflammation, fibrosis, and precision therapeutics.Molecular biology reports · 2026Review
- Improvement of the Stability of Functionalized PVA Nanofibers for Sensitive Compound Incorporation by Gentle Freeze-Thaw Treatment.ACS omega · 2026Article
1,447 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The cellular and molecular mechanisms underpinning tissue repair and its failure to heal are still poorly understood, and current therapies are limited. Poor wound healing after trauma, surgery, acute illness, or chronic disease conditions affects millions of people worldwide each year and is the consequence of poorly regulated elements of the healthy tissue repair response, including inflammation, angiogenesis, matrix deposition, and cell recruitment. Failure of one or several of these cellular processes is generally linked to an underlying clinical condition, such as vascular disease, diabetes, or aging, which are all frequently associated with healing pathologies. The search for clinical strategies that might improve the body's natural repair mechanisms will need to be based on a thorough understanding of the basic biology of repair and regeneration. In this review, we highlight emerging concepts in tissue regeneration and repair, and provide some perspectives on how to translate current knowledge into viable clinical approaches for treating patients with wound-healing pathologies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.