ArticleProceedings of the National Academy of Sciences of the United States of America2014
Intrinsically organized resting state networks in the human spinal cord.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Who cites it
60 citing papers in PubMed, 107 citations in OpenAlex.
- Spinal cord structural and functional architecture and its shared organization with the brain across the adult lifespan.Nature communications · 2026Article
- Functional magnetic resonance imaging insights into nociceptive signal processing network in rat lumbar spinal cord.Pain reports · 2026Article
- Neptune: a toolbox for spinal cord functional MRI data processing and quality assurance.bioRxiv : the preprint server for biology · 2026Article
- Relationships Between Intra-Spinal Resting-State Functional Connectivity and Electrophysiology Following Spinal Cord Injury.Human brain mapping · 2025Article
- Coupling of Low Frequency Hemodynamic Oscillations Between the Brain and Spinal Cord.Human brain mapping · 2025Article
- Mapping the white-matter functional connectome: a personal perspective.Psychoradiology · 2025Review
- Changes in functional connectivity in relapsing-remitting multiple sclerosis spinal cord measured via region-based and data-driven analyses.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Characteristic BOLD signals are detectable in white matter of the spinal cord at rest and after a stimulus.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Thermal stimulus task fMRI in the cervical spinal cord at 7 Tesla.Human brain mapping · 2024Article
- Systematic investigation of cerebellar functional alterations and their association with surgical outcomes in patients with degenerative cervical myelopathy: a resting-state fMRI study.La Radiologia medica · 2024Article
- Spinal fMRI demonstrates segmental organisation of functionally connected networks in the cervical spinal cord: A test-retest reliability study.Human brain mapping · 2024Article
- Article
- Lumbosacral spinal cord functional connectivity at rest: From feasibility to reliability.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Cerebro-spinal somatotopic organization uncovered through functional connectivity mapping.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Reliability of task-based fMRI in the dorsal horn of the human spinal cord.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Recent developments and future avenues for human corticospinal neuroimaging.Frontiers in human neuroscience · 2024Review
- Spinal Cord fMRI: A New Window into the Central Nervous System.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2023Review
- Detection of resting-state functional connectivity in the lumbar spinal cord with 3T MRI.Scientific reports · 2023Article
- Longitudinal multiparametric MRI of traumatic spinal cord injury in animal models.Magnetic resonance imaging · 2023Review
- Reliability of resting-state functional connectivity in the human spinal cord: Assessing the impact of distinct noise sources.NeuroImage · 2023Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
Spontaneous fluctuations in functional magnetic resonance imaging (fMRI) signals of the brain have repeatedly been observed when no task or external stimulation is present. These fluctuations likely reflect baseline neuronal activity of the brain and correspond to functionally relevant resting-state networks (RSN). It is not known however, whether intrinsically organized and spatially circumscribed RSNs also exist in the spinal cord, the brain's principal sensorimotor interface with the body. Here, we use recent advances in spinal fMRI methodology and independent component analysis to answer this question in healthy human volunteers. We identified spatially distinct RSNs in the human spinal cord that were clearly separated into dorsal and ventral components, mirroring the functional neuroanatomy of the spinal cord and likely reflecting sensory and motor processing. Interestingly, dorsal (sensory) RSNs were separated into right and left components, presumably related to ongoing hemibody processing of somatosensory information, whereas ventral (motor) RSNs were bilateral, possibly related to commissural interneuronal networks involved in central pattern generation. Importantly, all of these RSNs showed a restricted spatial extent along the spinal cord and likely conform to the spinal cord's functionally relevant segmental organization. Although the spatial and temporal properties of the dorsal and ventral RSNs were found to be significantly different, these networks showed significant interactions with each other at the segmental level. Together, our data demonstrate that intrinsically highly organized resting-state fluctuations exist in the human spinal cord and are thus a hallmark of the entire central nervous system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.