SynthesisInternal and emergency medicine2015
Epidemiology of venous thromboembolism in patients with liver diseases: a systematic review and meta-analysis.
Synthesis in Internal and emergency medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Incidence and risk factors of venous and arterial thromboembolism events in lung cancer patients treated with immune checkpoint inhibitors.Frontiers in pharmacology · 2026Article
- CiThroModel Improves Prediction of Symptomatic Venous Thromboembolism in Hospitalized Patients With Cirrhosis Without Hepatocellular Carcinoma.United European gastroenterology journal · 2025Article
- Multimorbidity disease clusters are associated with venous thromboembolism: an extended cross-sectional national study.Journal of thrombosis and thrombolysis · 2024Article
- A hypothesis - generating Swedish extended national cross-sectional family study of multimorbidity severity and venous thromboembolism.BMJ open · 2023Article
- Prevalence of chronic venous insufficiency and deep vein thrombosis in cirrhotic patients.Frontiers in medicine · 2023Article
- Safety of direct oral anticoagulants compared to warfarin in cirrhotic patients with atrial fibrillation.The Korean journal of internal medicine · 2022Article
- The concept of rebalanced hemostasis in patients with liver disease: Communication from the ISTH SSC working group on hemostatic management of patients with liver disease.Journal of thrombosis and haemostasis : JTH · 2021Article
- Review of Medical Therapies for the Management of Pulmonary Embolism.Medicina (Kaunas, Lithuania) · 2021Review
- Anticoagulation in patients with advanced liver disease: an open issue.Internal and emergency medicine · 2021Review
- COVID-19 With Preexisting Hypercoagulability Digestive Disease.Frontiers in medicine · 2020Review
- Epidemiology of venous thromboembolism in Africa: a systematic review and meta-analysis protocol.BMJ open · 2017Article
- Recurrent Deep Vein Thrombosis After the First Venous Thromboembolism Event: A Single-Institution Experience.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- Thrombosis and anticoagulation in the setting of renal or liver disease.Hematology. American Society of Hematology. Education Program · 2016Review
- Association of conventional haemostasis and coagulation tests with the risk of acute upper gastrointestinal bleeding in liver cirrhosis: a retrospective study.Gastroenterology report · 2016Article
- Epidemiology, Risk Factors, and In-Hospital Mortality of Venous Thromboembolism in Liver Cirrhosis: A Single-Center Retrospective Observational Study.Medical science monitor : international medical journal of experimental and clinical research · 2016Observational
- Severe hepatic dysfunction is associated with venous thromboembolic events in phase 1 clinical trials.Thrombosis research · 2015Article
- Venous thromboembolism in patients with liver diseases.Internal and emergency medicine · 2015Article
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Abstract
The risk of venous thromboembolism (VTE) may be increased in patients with liver diseases. A systematic review and meta-analysis were conducted to analyze the epidemiology of VTE in such patients. All relevant studies were searched via the PubMed, EMBASE, and Cochrane Library databases. The incidence and prevalence of VTE were pooled using random-effect models. Subgroup analyses were conducted according to the type of VTE [deep vein thrombosis (DVT), pulmonary embolism (PE)], type of liver disease (liver cirrhosis alone/unclassified liver diseases or non-cirrhotics), region in which the study was performed (USA/Europe/Asia), number of total observed patients with liver diseases (>1,000/<1,000 patients), study quality (high/low), and methods for identifying the cases (ICD codes/clinical charts). Of 4,843 papers initially identified, 20 were included. The incidence of VTE varied from 0.33 to 6.32 % in 14 studies with a pooled value of 1 % (95 % confidence interval (CI) 0.7-1.3 %). The pooled incidence of DVT and PE was 0.6 % (95 % CI 0.4-0.8 %) and 0.28 % (95 % CI 0.13-0.49 %), respectively. The prevalence of VTE varied from 0.6 to 4.69 % in six studies with a pooled value of 1.0 % (95 % CI 0.7-1.2 %). The pooled prevalence of DVT and PE was 0.7 % (95 % CI 0.6-0.9 %) and 0.36 % (95 % CI 0.13-0.7 %), respectively. The heterogeneity was statistically significant in the main and subgroup meta-analyses. In conclusion, about 1 % of patients with liver diseases develop or are diagnosed with VTE during their hospitalizations. However, the epidemiological data are very heterogeneous among studies.
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