ArticleMolecular genetics and genomics : MGG2015
Differential lncRNA expression profiles in brown and white adipose tissues.
Article in Molecular genetics and genomics : MGG, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- The multifaceted regulation of white adipose tissue browning and their therapeutic potential.Journal of physiology and biochemistry · 2025Review
- Review
- The role of long non-coding RNAs in the development of adipose cells.Non-coding RNA research · 2023Review
- Unraveling the molecular mechanisms of hyperlipidemia using integrated lncRNA and mRNA microarray data.Experimental and therapeutic medicine · 2022Article
- CircRNA-mediated regulation of brown adipose tissue adipogenesis.Frontiers in nutrition · 2022Article
- Integrative Analysis of lncRNA-miRNA-mRNA Regulatory Network Reveals the Key lncRNAs Implicated Potentially in the Differentiation of Adipocyte in Goats.Frontiers in physiology · 2022Article
- Role of long non-coding RNAs in adipogenesis: State of the art and implications in obesity and obesity-associated diseases.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2021Review
- RNA-seq Characterization of Sex-Differences in Adipose Tissue of Obesity Affected Patients: Computational Analysis of Differentially Expressed Coding and Non-Coding RNAs.Journal of personalized medicine · 2021Article
- Article
- RNA-Seq Analysis Identifies Differentially Expressed Genes Insubcutaneous Adipose Tissuein Qaidamford Cattle, Cattle-Yak, and Angus Cattle.Animals : an open access journal from MDPI · 2019Article
- Identification and association of novel lncRNA pouMU1 gene mutations with chicken performance traits.Journal of genetics · 2017Article
- Long non-coding RNAs could act as vectors for paternal heredity of high fat diet-induced obesity.Oncotarget · 2017Article
- Genome-Wide Analysis of lncRNA and mRNA Expression During Differentiation of Abdominal Preadipocytes in the Chicken.G3 (Bethesda, Md.) · 2017Article
- Analysis of long noncoding RNA and mRNA using RNA sequencing during the differentiation of intramuscular preadipocytes in chicken.PloS one · 2017Article
- ARN: Analysis and Visualization System for Adipogenic Regulation Network Information.Scientific reports · 2016Article
- ARN: analysis and prediction by adipogenic professional database.BMC systems biology · 2016Article
- Long noncoding RNAs in regulating adipogenesis: new RNAs shed lights on obesity.Cellular and molecular life sciences : CMLS · 2016Review
- Progress and prospects of long noncoding RNAs in lipid homeostasis.Molecular metabolism · 2016Review
- Long Noncoding RNAs: A New Regulatory Code in Metabolic Control.Trends in biochemical sciences · 2015Review
- Regulatory networks of non-coding RNAs in brown/beige adipogenesis.Bioscience reports · 2015Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long non-coding RNAs (lncRNAs) are an important class of pervasive genes involved in a variety of biological functions. It can serve as key co-activators of proteins involved in transcriptional regulation. Studies have found that white and brown adipocytes both originate from the mesoderm. However, it remains unclear whether lncRNAs function during adipogenesis or in energy metabolism in brown adipose tissue (BAT) and white adipose tissue (WAT). In this study, we used lncRNA microarray technology to evaluate differences in the lncRNA expression profiles of WAT and BAT. We observed 735 up-regulated and 877 down-regulated lncRNAs (fold change >4.0). To reveal the potential functions of these lncRNAs, we applied GO and pathway analyses to study the differentially expressed lncRNAs. We found that AK142386 and AK133540 may affect adipogenesis and metabolism. Our data indicate that AK142386 and AK133540 may be involved in BAT and WAT development through their target genes Hoxa3 and Acad10. Together, we have identified numerous lncRNAs and these lncRNAs can potentially serve as a required component for proper adipogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.