ArticleExtremophiles : life under extreme conditions2015
Different effects of MglA and MglB on pilus-mediated functions and natural competence in Thermus thermophilus.
Article in Extremophiles : life under extreme conditions, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Review
- Rapid water flow triggers long-distance positive rheotaxis for thermophilic bacteria.The ISME journal · 2025Article
- Combinatorial control of type IVa pili formation by the four polarized regulators MglA, SgmX, FrzS, and SopA.Journal of bacteriology · 2024Article
- Identification of the mutual gliding locus as a factor for gut colonization in non-native bee hosts using the ARTP mutagenesis.Microbiome · 2024Article
- The small GTPase MglA together with the TPR domain protein SgmX stimulates type IV pili formation inProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Serum Albumin and Ca2+ Are Natural Competence Inducers in the Human Pathogen Acinetobacter baumannii.Antimicrobial agents and chemotherapy · 2016Article
- Topology and Structure/Function Correlation of Ring- and Gate-forming Domains in the Dynamic Secretin Complex of Thermus thermophilus.The Journal of biological chemistry · 2016Article
- Article
- Extremely thermophilic microorganisms as metabolic engineering platforms for production of fuels and industrial chemicals.Frontiers in microbiology · 2015Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The thermophilic bacterium Thermus thermophilus is known for its high natural competence. Uptake of DNA is mediated by a DNA translocator that shares components with type IV pili. Localization and function of type IV pili in other bacteria depend on the cellular localization at the poles of the bacterium, a process that involves MglA and MglB. T. thermophilus contains homologs of MglA and MglB. The genes encoding MglA and MglB were deleted and the physiology of the mutants was studied. Deletion of the genes individually or in tandem had no effect on pili formation but pili lost their localization at the poles. The mutants abolished pilus-mediated functions such as twitching motility and adherence but had no effect on uptake of DNA by natural competence. These data demonstrate that MglA and MglB are dispensable for natural transformation and are consistent with the hypothesis that uptake of DNA does not depend on type IV pili or their cellular localization.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.