ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Excitation and inhibition compete to control spiking during hippocampal ripples: intracellular study in behaving mice.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers.
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Who cites it
88 citing papers in PubMed.
- Closed-loop modulation of sleep in children undergoing intracranial recordings.Cell reports. Medicine · 2026Trial
- Place and behavioral modulation of hippocampal neurons during immobility.Nature communications · 2026Article
- Designer indicators for two-photon recording of subthreshold voltage dynamics.Nature methods · 2026Article
- Designer indicators for two-photon recording of subthreshold voltage dynamics.bioRxiv : the preprint server for biology · 2026Article
- Neuronal spiking in the mammalian forebrain is dominated by a heterogeneous ground state.Neuron · 2026Article
- Variation in the Involvement of Hippocampal Pyramidal Cell Subtypes in Spatial Learning Tasks.eNeuro · 2025Article
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- Differential contributions of CA3 and entorhinal cortex inputs to ripple patterns in the hippocampus.iScience · 2025Article
- Electroanatomy of hippocampal activity patterns: theta, gamma waves, sharp wave-ripples, and dentate spikes.Frontiers in behavioral neuroscience · 2025Article
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- Theta-gamma coupling: nonlinearity as a universal cross-frequency coupling mechanism.Frontiers in behavioral neuroscience · 2025Article
- Regulation of sharp wave-ripples by cholecystokinin-expressing interneurons and parvalbumin-expressing basket cells in the hippocampal CA3 region.Frontiers in computational neuroscience · 2025Article
- Synaptic acetylcholine induces sharp wave ripples in the basolateral amygdala through nicotinic receptors.bioRxiv : the preprint server for biology · 2024Article
- Topography of putative bidirectional interaction between hippocampal sharp wave ripples and neocortical slow oscillations.bioRxiv : the preprint server for biology · 2024Article
- Inhibitory plasticity supports replay generalization in the hippocampus.Nature neuroscience · 2024Article
- A hippocampal circuit mechanism to balance memory reactivation during sleep.Science (New York, N.Y.) · 2024Article
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- Review
- Silencing CA1 pyramidal cells output reveals the role of feedback inhibition in hippocampal oscillations.Nature communications · 2024Article
28 more citing papers are in PubMed but not listed here.
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7 authors.
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Abstract
High-frequency ripple oscillations, observed most prominently in the hippocampal CA1 pyramidal layer, are associated with memory consolidation. The cellular and network mechanisms underlying the generation of the rhythm and the recruitment of spikes from pyramidal neurons are still poorly understood. Using intracellular, sharp electrode recordings in freely moving, drug-free mice, we observed consistent large depolarizations in CA1 pyramidal cells during sharp wave ripples, which are associated with ripple frequency fluctuation of the membrane potential ("intracellular ripple"). Despite consistent depolarization, often exceeding pre-ripple spike threshold values, current pulse-induced spikes were strongly suppressed, indicating that spiking was under the control of concurrent shunting inhibition. Ripple events were followed by a prominent afterhyperpolarization and spike suppression. Action potentials during and outside ripples were orthodromic, arguing against ectopic spike generation, which has been postulated by computational models of ripple generation. These findings indicate that dendritic excitation of pyramidal neurons during ripples is countered by shunting of the membrane and postripple silence is mediated by hyperpolarizing inhibition.
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