ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2014
Optogenetic mapping after stroke reveals network-wide scaling of functional connections and heterogeneous recovery of the peri-infarct.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 58 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
58 citing papers in PubMed, 115 citations in OpenAlex.
- Long-range axon branching: contributions to brain network plasticity and repair.Nature reviews. Neuroscience · 2026Review
- Hemodynamic and Electrophysiological Progression of the Rose Bengal Photothrombotic Stroke Model in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Microglia interact with dendritic spines and regulate spine numbers after brain injury following resuscitation from a cardiac arrest.Experimental neurology · 2025Article
- Combining gamma neuromodulation and robotic rehabilitation after a stroke restores parvalbumin interneuron dynamics and improves motor recovery in mice.PLoS biology · 2025Article
- Astrocytic BEST1 can serve as a target for functional recovery after ischemic stroke.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
- Neural repair mechanisms after ischemic stroke.Inflammation and regeneration · 2025Review
- A critical opinion on adult endogenous neurogenesis as a brain repair mechanism after traumatic brain injury.Frontiers in behavioral neuroscience · 2025Article
- Article
- Deep brain stimulation combined with morroniside promotes neural plasticity and motor functional recovery after ischemic stroke.Frontiers in pharmacology · 2024Article
- Rethinking Remapping: Circuit Mechanisms of Recovery after Stroke.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Review
- Application of optogenetic glial cells to neuron-glial communication.Frontiers in cellular neuroscience · 2023Review
- Mapping correlated neurological deficits after stroke to distributed brain networks.Brain structure & function · 2022Review
- Subcortical-cortical dynamical states of the human brain and their breakdown in stroke.Nature communications · 2022Article
- Functional connectivity drives stroke recovery: shifting the paradigm from correlation to causation.Brain : a journal of neurology · 2022Review
- Review
- Longitudinal functional imaging of VIP interneurons reveals sup-population specific effects of stroke that are rescued with chemogenetic therapy.Nature communications · 2021Article
- Brain-wide neural dynamics of poststroke recovery induced by optogenetic stimulation.Science advances · 2021Article
- Peripheral sensory stimulation elicits global slow waves by recruiting somatosensory cortex bilaterally.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Encouraging an excitable brain state: mechanisms of brain repair in stroke.Nature reviews. Neuroscience · 2021Review
- Optogenetic Interrogation of Circuits Following Neurotrauma.Frontiers in molecular neuroscience · 2021Review
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
We used arbitrary point channelrhodopsin-2 (ChR2) stimulation and wide-scale voltage sensitive dye (VSD) imaging in mice to map altered cortical connectivity at 1 and 8 weeks after a targeted cortical stroke. Network analysis based on optogenetic stimulation revealed a symmetrical sham network with distinct sensorimotor and association groupings. This symmetry was disrupted after stroke: at 1 week after stroke, we observed a widespread depression of optogenetically evoked activity that extended to the non-injured hemisphere; by 8 weeks, significant recovery was observed. When we considered the network as a whole, scaling the ChR2-evoked VSD responses from the stroke groups to match the sham group mean resulted in a relative distribution of responses that was indistinguishable from the sham group, suggesting network-wide down-scaling and connectional diaschisis after stroke. Closer inspection revealed that connections that had little connectivity with the peri-infarct, such as contralateral visual areas, tended to escape damage, whereas some connections near the peri-infarct were more severely affected. When connections within the peri-infarct were isolated, we did not observe equal down-scaling of responses after stroke. Peri-infarct sites that had weak connection strength in the sham condition tended to have the greatest relative post-stroke recovery. Our findings suggest that, during recovery, most cortical areas undergo homeostatic upscaling, resulting in a relative distribution of responses that is similar to the pre-stroke (sham) network, albeit still depressed. However, recovery within the peri-infarct zone is heterogeneous and these cortical points do not follow the recovery scaling factor expected for the entire network.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.