ArticleNeurology2015
Rates and risk factors for progression to incident dementia vary by age in a population cohort.
Article in Neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Population attributable fractions of a wide range of peripheral diseases for the burden of dementia.Nature human behaviour · 2026Pooled it
- Stroke and dementia risk: A systematic review and meta-analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2018Pooled it
- Orthostatic hypotension and symptomatic subclinical orthostatic hypotension increase risk of cognitive impairment: an integrated evidence review and analysis of a large older adult hypertensive cohort.European heart journal · 2018Pooled it
- Rate of incident dementia and care needs among older adults with new traumatic brain injury: a population-based cohort study.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2025Article
- Factors associated with dementia among older people in Malaysia: Findings from National Health and Morbidity Survey.Australasian journal on ageing · 2025Article
- Social determinants of health and mild cognitive impairment in a diverse community sample.Journal of the American Geriatrics Society · 2025Article
- Multimodal neuroimaging biomarkers and subtle cognitive decline in a population-based cohort without dementia.Journal of Alzheimer's disease : JAD · 2025Article
- Serum Uric Acid Levels Associated with Outcomes of Neurodegenerative Disorders and Brain Health: Findings from the UK Biobank.The journal of nutrition, health & aging · 2024Article
- Self-reported sleep in relation to risk of dementia a quarter of a century later at age 90+:Behavioral sleep medicine · 2023Article
- The association between dietary patterns, plasma lipid profiles, and inflammatory potential in a vascular dementia cohort.Aging medicine (Milton (N.S.W)) · 2023Article
- The Associations of Dietary Copper With Cognitive Outcomes.American journal of epidemiology · 2022Article
- Risk of conversion from mild cognitive impairment to dementia in low- and middle-income countries: A systematic review and meta-analysis.Alzheimer's & dementia (New York, N. Y.) · 2022Review
- Estimation of dementia prevalence at the local level in the United States.Alzheimer's & dementia (New York, N. Y.) · 2021Article
- Baseline Neuroimaging Predicts Decline to Dementia From Amnestic Mild Cognitive Impairment.Frontiers in aging neuroscience · 2021Article
- Predicting resistance to amyloid-beta deposition and cognitive resilience in the oldest-old.Neurology · 2020Observational
- Aging, Diabetes, Obesity, and Cognitive Decline: A Population-Based Study.Journal of the American Geriatrics Society · 2020Article
- APOE-ε4 Genotype and Dementia Before and After Transient Ischemic Attack and Stroke: Population-Based Cohort Study.Stroke · 2020Article
- Declining Incident Dementia Rates Across Four Population-Based Birth Cohorts.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- Prospective associations between pulse pressure and cognitive performance in Chinese middle-aged and older population across a 5-year study period.Alzheimer's research & therapy · 2018Article
- Diabetes, Prediabetes, and Brain Volumes and Subclinical Cerebrovascular Disease on MRI: The Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS).Diabetes care · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectiveTo estimate rate of progression from normal cognition or mild impairment to dementia, and to identify potential risk and protective factors for incident dementia, based on age at dementia onset in a prospective study of a population-based cohort (n = 1,982) aged 65 years and older.
methodsFollowing the cohort annually for up to 5 years, we estimated incidence of dementia (Clinical Dementia Rating ≥1) among individuals previously normal or mildly impaired (Clinical Dementia Rating 0 or 0.5). In the whole cohort, and also stratified by median onset age, we examined several vascular, metabolic, and inflammatory variables as potential risk factors for developing dementia, using interval-censored survival models.
resultsBased on 67 incident cases of dementia, incidence rate (per 1,000 person-years) was 10.0 overall, 5.8 in those with median onset age of 87 years or younger, and 31.5 in those with onset age after 87 years. Adjusting for demographics, the risk of incident dementia with onset age of 87 years or younger (n = 33) was significantly increased by baseline smoking, stroke, low systolic blood pressure, and APOE*4 genotype, and reduced by current alcohol use. Among those with dementia with onset after 87 years (n = 34), no risk or protective factor was significant.
conclusionRisk and protective factors were only found for incident dementia with onset before the median onset age of 87 years, and not for those with later onset. Either unexplored risk factors explain the continued increase in incidence with age, or unknown protective factors are allowing some individuals to delay onset into very old age.
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