ArticleJournal of magnetic resonance imaging : JMRI2015
Simultaneous imaging of radiation-induced cerebral microbleeds, arteries and veins, using a multiple gradient echo sequence at 7 Tesla.
Article in Journal of magnetic resonance imaging : JMRI, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Ultra-high-field 7-Tesla MRI in neuro-oncology: a narrative review of current applications and future directions.Quantitative imaging in medicine and surgery · 2026Review
- New MRI findings of late delayed radiation injuries in long-term survivors after radiotherapy: punctate enhancing dot-, oval-, or rod-like lesions.Neuroradiology · 2026Article
- SWI by 7T MR Imaging for the Microscopic Imaging Diagnosis of Astrocytic and Oligodendroglial Tumors.AJNR. American journal of neuroradiology · 2022Article
- Functional network alterations in young brain tumor patients with radiotherapy-induced memory impairments and vascular injury.Frontiers in neurology · 2022Article
- Relationship between 7T MR-angiography features of vascular injury and cognitive decline in young brain tumor patients treated with radiation therapy.Journal of neuro-oncology · 2021Article
- Rate of radiation-induced microbleed formation on 7T MRI relates to cognitive impairment in young patients treated with radiation therapy for a brain tumor.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2021Article
- A Fully Automated Method for Segmenting Arteries and Quantifying Vessel Radii on Magnetic Resonance Angiography Images of Varying Projection Thickness.Frontiers in neuroscience · 2020Article
- Toward Automatic Detection of Radiation-Induced Cerebral Microbleeds Using a 3D Deep Residual Network.Journal of digital imaging · 2019Article
- Risk factors of radiotherapy-induced cerebral microbleeds and serial analysis of their size compared with white matter changes: A 7T MRI study in 113 adult patients with brain tumors.Journal of magnetic resonance imaging : JMRI · 2019Article
- Remote brain microhaemorrhages may predict haematoma in glioma patients treated with radiation therapy.European radiology · 2018Article
- Initial Investigation into Microbleeds and White Matter Signal Changes following Radiotherapy for Low-Grade and Benign Brain Tumors Using Ultra-High-Field MRI Techniques.AJNR. American journal of neuroradiology · 2017Article
- Imaging in Vascular Access.Cardiovascular engineering and technology · 2017Review
- Cerebral microhemorrhages: mechanisms, consequences, and prevention.American journal of physiology. Heart and circulatory physiology · 2017Review
- The effects of anti-angiogenic therapy on the formation of radiation-induced microbleeds in normal brain tissue of patients with glioma.Neuro-oncology · 2016Article
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Authors and funding
8 authors.
Funding
Abstract
backgroundThe purpose of this study was to implement and evaluate the utility of a multi-echo sequence at 7 Tesla (T) for simultaneous time-of-flight (TOF) MR-angiography (MRA) and susceptibility-weighted imaging (SWI) of radiation-induced cerebral microbleeds (CMBs), intracranial arteries, and veins.
methodsA four-echo gradient-echo sequence was implemented on a 7T scanner. The first echo was used to create TOF-MRA images, while the remaining echoes were combined to visualize CMBs and veins on SWI images. The sequence was evaluated on eight brain tumor patients with known radiation-induced CMBs. Single-echo images were also acquired to visually and quantitatively compare the contrast-to-noise ratio (CNR) of small- and intermediate-vessels between acquisitions. The number of CMBs detected with each acquisition was also quantified. Statistical significance was determined using a Wilcoxon signed-rank test.
resultsCompared with the single-echo sequences, the CNR of small and intermediate arteries increased 7.6% (P < 0.03) and 9.5% (P = 0.06), respectively, while the CNR of small and intermediate veins were not statistically different between sequences (P = 0.95 and P = 0.46, respectively). However, these differences were not discernible by visual inspection. Also the multi-echo sequence detected 18.3% more CMBs (P < 0.008) due to higher slice resolution.
conclusionThe proposed 7T multi-echo sequence depicts arteries, veins, and CMBs on a single image to facilitate quantitative evaluation of radiation-induced vascular injury.
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