ArticleNature communications2014
Khoisan hunter-gatherers have been the largest population throughout most of modern-human demographic history.
Article in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Revisiting the African mtDNA landscape through complete mitochondrial genomes.Communications biology · 2026Article
- PSMC-FAC: Automated Optimization of False-Negative Rate Corrections for Low-Coverage PSMC-Based Demographic Inference.Biology · 2026Article
- Does Effective Population Size Govern Evolutionary Differences in Telomere Length?Genome biology and evolution · 2024Article
- Evolutionary Genetics and Admixture in African Populations.Genome biology and evolution · 2023Review
- Article
- Still Standing Inside: A Local Idiom Related to Trauma among Namibian Speakers of Khoekhoegowab.International journal of environmental research and public health · 2022Article
- Hunter-gatherer genomes reveal diverse demographic trajectories during the rise of farming in Eastern Africa.Current biology : CB · 2022Article
- Genome Sequencing of a Gray Wolf from Peninsular India Provides New Insights into the Evolution and Hybridization of Gray Wolves.Genome biology and evolution · 2022Article
- Comparison of sequencing data processing pipelines and application to underrepresented African human populations.BMC bioinformatics · 2021Article
- The genomic prehistory of peoples speaking Khoisan languages.Human molecular genetics · 2021Review
- The deep population history in Africa.Human molecular genetics · 2021Review
- Khoe-San Genomes Reveal Unique Variation and Confirm the Deepest Population Divergence in Homo sapiens.Molecular biology and evolution · 2020Article
- A Late Holocene community burial area: Evidence of diverse mortuary practices in the Western Cape, South Africa.PloS one · 2020Article
- Contemporary Demographic Reconstruction Methods Are Robust to Genome Assembly Quality: A Case Study in Tasmanian Devils.Molecular biology and evolution · 2019Article
- Runs of homozygosity in sub-Saharan African populations provide insights into complex demographic histories.Human genetics · 2019Article
- Genetic Affinities among Southern Africa Hunter-Gatherers and the Impact of Admixing Farmer and Herder Populations.Molecular biology and evolution · 2019Article
- Whole-genome sequence analysis of a Pan African set of samples reveals archaic gene flow from an extinct basal population of modern humans into sub-Saharan populations.Genome biology · 2019Article
- African evolutionary history inferred from whole genome sequence data of 44 indigenous African populations.Genome biology · 2019Article
- Nicotinamide and Demographic and Disease transitions: Moderation is Best.International journal of tryptophan research : IJTR · 2019Review
- African genetic diversity provides novel insights into evolutionary history and local adaptations.Human molecular genetics · 2018Review
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The Khoisan people from Southern Africa maintained ancient lifestyles as hunter-gatherers or pastoralists up to modern times, though little else is known about their early history. Here we infer early demographic histories of modern humans using whole-genome sequences of five Khoisan individuals and one Bantu speaker. Comparison with a 420 K SNP data set from worldwide individuals demonstrates that two of the Khoisan genomes from the Ju/'hoansi population contain exclusive Khoisan ancestry. Coalescent analysis shows that the Khoisan and their ancestors have been the largest populations since their split with the non-Khoisan population ~100-150 kyr ago. In contrast, the ancestors of the non-Khoisan groups, including Bantu-speakers and non-Africans, experienced population declines after the split and lost more than half of their genetic diversity. Paleoclimate records indicate that the precipitation in southern Africa increased ~80-100 kyr ago while west-central Africa became drier. We hypothesize that these climate differences might be related to the divergent-ancient histories among human populations.
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