Evidence map›Paper›PMID 25471106›Full record

ArticleMedical principles and practice : international journal of the Kuwait University, Health Science Centre2015

In vitro adhesion of oral Candida dubliniensis isolates to acrylic denture surfaces following brief exposure to sub-cidal concentrations of polyenes, azoles and chlorhexidine.

Arjuna N B Ellepola, Bobby K Joseph, Yacoub Altarakemah, Lakshman P Samaranayake, Sukumaran Anil, Mohamed Hashem, Zia U Khan

Open access · diamondAbstract readComparative Study
In one paragraph

Article in Medical principles and practice : international journal of the Kuwait University, Health Science Centre, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Should local drug delivery systems be used in dentistry?Drug delivery and translational research · 2022
    Review
  5. Article
  6. In vitro Post-Antifungal Effect of Posaconazole and Its Impact on Adhesion-Related Traits and Hemolysin Production of Oral Candida dubliniensis Isolates.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2019
    Article
  7. Rapid and Accurate Identification of Candida albicans and Candida dubliniensis by Real-Time PCR and Melting Curve Analysis.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2018
    Article
  8. Impact of Brief Exposure to Drugs with Antifungal Properties on the Susceptibility of Oral Candida dubliniensis Isolates to Lysozyme and Lactoferrin.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2018
    Article
  9. Effects of Fixed and Removable Space Maintainers on Plaque Accumulation, Periodontal Health, Candidal and Enterococcus Faecalis Carriage.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2015
    Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Arjuna N B EllepolaDepartments of Bioclinical, Diagnostics and Restorative Sciences, Faculty of Dentistry, Kuwait University, Jabriya, Kuwait.
Bobby K Joseph
Yacoub Altarakemah
Lakshman P Samaranayake
Sukumaran Anil
Mohamed Hashem
Zia U Khan
King Saud University · SAKuwait University · KWUniversity of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesWe aimed to investigate the effect of brief exposure to sub-cidal concentrations of nystatin, amphotericin B, ketoconazole, fluconazole and chlorhexidine gluconate on the adhesion of oral Candida dubliniensis isolates to the surface of acrylic dentures.

methodsAfter determining the minimum inhibitory concentration of each drug, 20 oral isolates of C. dubliniensis were exposed to sub-cidal concentrations of the drugs for 1 h. The drugs were then removed by dilution, and the adhesion of the isolates to denture acrylic strips was assessed by an in vitro adhesion assay.

resultsCompared to the controls, exposure to nystatin, amphotericin B, ketoconazole, fluconazole and chlorhexidine gluconate suppressed the ability of C. dubliniensis isolates to adhere to acrylic denture surfaces with a reduction of 74.68, 74.27, 57.31, 44.57 and 56.53% (p < 0.001 for all drugs), respectively.

conclusionsBrief exposure to sub-cidal concentrations of anti-mycotics suppressed the adhesion of C. dubliniensis oral isolates to acrylic denture surfaces.

Indexed as

Analysis of VarianceAntifungal AgentsAnti-Infective Agents, LocalAzolesCandidaChlorhexidineDental ClinicsDenturesHumansKuwaitMicrobial Sensitivity TestsPolyenesPolymethyl MethacrylateAntifungal AgentsAnti-Infective Agents, LocalAzolesChlorhexidinePolyenesPolymethyl Methacrylate

Identifiers

PMID25471106
PMCPMC5588188
OpenAlexW2087434904

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.