Trial reportBMC psychiatry2014
Reducing the duration of untreated psychosis and its impact in the U.S.: the STEP-ED study.
Trial report in BMC psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02069925 (STEP-ED), which is not on this map. Cited by 48 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
STEP-ED: Reducing Duration of Untreated Psychosis and Its Impact in the U.S.
Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 93 citations in OpenAlex.
- Can We Reduce the Duration of Untreated Psychosis? A Systematic Review and Meta-Analysis of Controlled Interventional Studies.Schizophrenia bulletin · 2018Pooled it
- The impact of Duration of Untreated Psychosis on functioning and quality of life over one year of Coordinated Specialty Care (CSC).PloS one · 2025Trial
- Effect of Technology-Enhanced Screening in Addition to Standard Targeted Clinician Education on the Duration of Untreated Psychosis: A Cluster Randomized Clinical Trial.JAMA psychiatry · 2023Trial
- Psychosis Mental Health Campaigns: A Scoping Review of Strategies and Outcomes.Early intervention in psychiatry · 2026Article
- Mind the delay: duration of untreated psychosis is associated with short-term outcomes in first-episode schizophrenia.Frontiers in psychiatry · 2026Article
- Enhancing Coordinated Specialty Care Through Early Detection: Impact of Reduced Duration of Untreated Psychosis.Schizophrenia bulletin · 2025Article
- Utilization of a psychosis consultation service: Early lessons from a statewide initiative.Schizophrenia research · 2025Article
- HONE: A learning health system platform for advancing early intervention in first episode psychosis.Schizophrenia research · 2025Article
- The STEP Learning Collaborative: A statewide Learning Healthcare System (LHS) for first episode psychosis.Schizophrenia research · 2025Article
- Insight and suicidality in first-episode psychosis: The mediating role of depression.Schizophrenia research · 2025Article
- The anomalous effect of COVID-19 pandemic restrictions on the duration of untreated psychosis.BJPsych open · 2024Article
- Exploring the acceptability, barriers, and facilitators to psychosis screening in the integrated behavioral health primary care setting: a qualitative study.BMC health services research · 2024Article
- The diagnostic accuracy of screening for psychosis spectrum disorders in behavioral health clinics integrated into primary care.Schizophrenia research · 2024Article
- The impact of early detection (ED) campaigns on care presentations: Beyond DUP reduction.Schizophrenia research · 2024Article
- Article
- Development of an anti-inflammatory diet for first-episode psychosis (FEP): a feasibility study protocol.Frontiers in nutrition · 2024Article
- Reorienting the focus from an individual to a community-level lens to improve the pathways through care for early psychosis in the United States.SSM. Mental health · 2023Article
- Changes in knowledge, behavioural expectations, self-efficacy, and stigma after an educational campaign about early psychosis for jail correction officers.Early intervention in psychiatry · 2023Article
- Sampling from different populations: Sociodemographic, clinical, and functional differences between samples of first episode psychosis individuals and clinical high-risk individuals who progressed to psychosis.Schizophrenia research · 2023Article
- Reducing Delay From Referral to Admission at a U.S. First-Episode Psychosis Service: A Quality Improvement Initiative.Psychiatric services (Washington, D.C.) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundEarly intervention services for psychotic disorders optimally interlock strategies to deliver: (i) Early Detection (ED) to shorten the time between onset of psychotic symptoms and effective treatment (i.e. Duration of Untreated Psychosis, DUP); and (ii) comprehensive intervention during the subsequent 2 to 5 years. In the latter category, are teams ('First-episode Services' or FES) that integrate several empirically supported treatments and adapt their delivery to younger patients and caregivers. There is an urgent need to hasten access to established FES in the U.S. Despite improved outcomes for those in treatment, these FES routinely engage patients a year or more after psychosis onset. The Scandinavian TIPS study was able to effectively reduce DUP in a defined geographic catchment. The guiding questions for this study are: can a U.S. adaptation of the TIPS approach to ED substantially reduce DUP and improve outcomes beyond existing FES? METHODS/
designThe primary aim is to determine whether ED can reduce DUP in the US, as compared to usual detection. ED will be implemented by one FES (STEP) based in southern Connecticut, and usual detection efforts will continue at a comparable FES (PREP(R)) serving the greater Boston metropolitan area. The secondary aim is to determine whether DUP reduction can improve presentation, engagement and early outcomes in FES care. A quasi-experimental design will compare the impact of ED on DUP at STEP compared to PREP(R) over 3 successive campaign years. The campaign will deploy 3 components that seek to transform pathways to care in 8 towns surrounding STEP. Social marketing approaches will inform a public education campaign to enable rapid and effective help-seeking behavior. Professional outreach and detailing to a wide variety of care providers, including those in the healthcare, educational and judicial sectors, will facilitate rapid redirection of appropriate patients to STEP. Finally, performance improvement measures within STEP will hasten engagement upon referral. DISCUSSION: STEP-ED will test an ED campaign adapted to heterogeneous U.S. pathways to care while also improving our understanding of these pathways and their impact on early outcomes.
trial registrationClinicalTrials.gov: NCT02069925 . Registered 20 February 2014.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.