ArticleBMC evolutionary biology2014
Integrative analysis of young genes, positively selected genes and lncRNAs in the development of Drosophila melanogaster.
Article in BMC evolutionary biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Developmental transcriptomics throughout the embryonic developmental process of Rhipicephalus turanicus reveals stage-specific gene expression profiles.Parasites & vectors · 2022Article
- Co-Expression Network and Time-Course Expression Analyses to Identify Silk Protein Regulatory Factors inInsects · 2022Article
- Pervasive translation of small open reading frames in plant long non-coding RNAs.Frontiers in plant science · 2022Review
- Contrasting patterns of molecular evolution in metazoan germ line genes.BMC evolutionary biology · 2019Article
- Multidimensional communication of microRNAs and long non-coding RNAs in lung cancer.Journal of cancer research and clinical oncology · 2019Review
- Genomic Complexity Places Less Restrictions on the Evolution of Young Coexpression Networks than Protein-Protein Interactions.Genome biology and evolution · 2016Article
- Genes from scratch--the evolutionary fate of de novo genes.Trends in genetics : TIG · 2015Review
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Authors and funding
5 authors.
Funding
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Abstract
backgroundYoung genes and genes under positive selection commonly contribute to adaptive phenotypic evolution. Early developmental stages are very important for establishing phenotypes, which might be helpful for studying the evolutionary patterns of these rapidly evolving genes.
resultsHere, we performed a weighted gene co-expression network analysis to identify modules of co-expressed genes at different stages of Drosophila melanogaster development. We found that young genes, including duplicated, orphan, and young lncRNA genes, are significantly enriched among modules associated with specific developmental stages. In addition, genes undergoing rapid amino acid sequence evolution driven by positive selection showed a similar proportion of essentiality with other genes, and enrichment in modules for specific developmental stages.
conclusionsOur integrative analysis revealed important roles for the origin of new genes and rapid amino acid sequence evolution in development that may account for specific phenotype evolution in Drosophila melanogaster.
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