Evidence map›Paper›PMID 25470984›Full record

ArticleTransfusion2015

Risk factors for retrovirus and hepatitis virus infections in accepted blood donors.

Brian Custer, Debra Kessler, Farnaz Vahidnia, German Leparc, David E Krysztof, Beth Shaz, Hany Kamel, Simone Glynn, Roger Y Dodd, Susan L Stramer and 1 more

Open access · greenAbstract read
In one paragraph

Article in Transfusion, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.

  1. A Systematic Review of Interventions Used to Increase Blood Donor Compliance with Deferral Criteria.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2021
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  10. Which Infectious Blood Donors Could Be Identified by the Donor History Questionnaire? - Comparison of Blood Donors Infected with HIV or HCV with Notified Cases from General Population in Germany.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2018
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  12. Recent viral infection in US blood donors and health-related quality of life (HRQOL).Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2017
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  15. Should Men who have sex with Men be allowed to donate blood in Israel?Israel journal of health policy research · 2016
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 2 countries.

Brian CusterBlood Systems Research Institute, San Francisco, California.
Debra KesslerNew York Blood Center, New York, New York.
Farnaz VahidniaBlood Systems Research Institute, San Francisco, California.
German LeparcOneBlood, Tampa, Florida.
David E KrysztofScientific Support Office, American Red Cross, Gaithersburg, Maryland.
Beth ShazNew York Blood Center, New York, New York.
Hany KamelBlood Systems, Inc., Scottsdale, Arizona.
Simone GlynnNational Heart, Lung and Blood Institute, National Institutes of Health, Rockville, Maryland.
Roger Y DoddHolland Laboratory, American Red Cross, Rockville, Maryland.
Susan L StramerScientific Support Office, American Red Cross, Gaithersburg, Maryland.
NHLBI Retrovirus Epidemiology Donor Study-II (REDS-II)
American Red Cross · USNew York Blood Center · USBlood Systems Research Institute · USNational Institutes of Health · USOneBlood · USUniversity of California, San Francisco · USVitalant · US

Funding

NHLBI NIH HHS HHSN268200417175C
6 · The paper itself

Abstract

backgroundRisk factor surveillance among infected blood donors provides information on the effectiveness of eligibility assessment and is critical for reducing risk of transfusion-transmitted infection. STUDY DESIGN AND

methodsAmerican Red Cross, Blood Systems, Inc., New York Blood Center, and OneBlood participated in a case-control study from 2010 to 2013. Donors with serologic and nucleic acid testing (NAT) or NAT-only confirmed human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), or serology-confirmed human T-lymphotropic virus (HTLV) infections (cases) and donors with false-positive results (controls) were interviewed for putative behavioral and demographic risks. Frequencies and adjusted odds ratios (AORs) from multivariable logistic regression analyses for each exposure in cases compared to controls are reported.

resultsIn the study, 196 HIV, 292 HBV, 316 HCV, and 198 HTLV cases, and 1587 controls were interviewed. For HIV, sex with an HIV+ person (AOR, 132; 95% confidence interval [CI], 27-650) and male-male sex (AOR, 62; 95% CI, 27-140) were primary risk factors. For HBV, first-time donor status (AOR, 16; 95% CI, 10-27), sex with an injection drug user (IDU; AOR, 11; 95% CI, 5-28), and black race (AOR, 11; 95% CI, 6-19) were primary. For HCV, IDU (AOR, 42; 95% CI, 13-136), first time (AOR, 18; 95% CI, 10-30), and a family member with hepatitis (AOR, 15; 95% CI, 6-40) were primary. For HTLV, sex with an IDU (AOR, 22; 95% CI, 10-48), 55 years old or more (AOR, 21; 95% CI, 8-52], and first time (AOR, 15; 95% CI, 9-24) were primary.

conclusionsDespite education efforts and risk screening, individuals with deferrable risks still donate; they may fail to understand or ignore or do not believe they have risk. Recipients have potential transfusion-transmitted infection risk because of nondisclosure by donors.

Indexed as

AdolescentAdultBlood DonorsFemaleHepatitis BHepatitis CHepatitis VirusesHIV InfectionsHumansMaleMiddle AgedRed CrossRetroviridaeRisk FactorsTransfusion ReactionYoung Adult

Identifiers

PMID25470984
PMCPMC4428964
OpenAlexW1496791474

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.