Evidence map›Paper›PMID 25470634›Full record

ArticleDiabetes & metabolic syndrome

Major depressive disorder and cardiometabolic disease risk among sub-Saharan African adults.

Bizu Gelaye, Michelle A Williams, Seblewengel Lemma, Yemane Berhane, Jesse R Fann, Ann Vander Stoep, Xiao-Hua Andrew Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes & metabolic syndrome. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Bizu GelayeDepartment of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA; Department of Epidemiology, University of Washington School of Public Health, Seattle, WA, USA. Electronic address: bgelaye@hsph.harvard.edu.
Michelle A WilliamsDepartment of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.
Seblewengel LemmaAddis Continental Institute of Public Health, Addis Ababa, Ethiopia.
Yemane BerhaneAddis Continental Institute of Public Health, Addis Ababa, Ethiopia.
Jesse R FannDepartment of Psychiatry and Behavioral Sciences, Rehabilitation Medicine, University of Washington, Seattle, WA, USA; Department of Epidemiology, University of Washington, Seattle, WA, USA.
Ann Vander StoepDepartment of Epidemiology, University of Washington School of Public Health, Seattle, WA, USA.
Xiao-Hua Andrew ZhouDepartment of Biostatistics, University of Washington School of Public Health, Seattle, WA, USA.
University of Washington · USAddis Continental Institute of Public Health · ETHarvard University · US

Funding

University of Washington MHIRT Training Program GrantT37MD001449 · NIMHD · UNIVERSITY OF WASHINGTON · PI WILLIAMS, MICHELLE A. · 2005 to 2018
$3.5M
NIMHD NIH HHS T37 MD001449NIMHD NIH HHS T37-MD001449
6 · The paper itself

Abstract

objectiveWe sought to evaluate the extent to which major depressive disorder (MDD) is associated with cardiometabolic diseases and risk factors.

methodsThis was a cross-sectional epidemiologic study of 1924 employed adults in Ethiopia. Structured interview was used to collect sociodemographic data, behavioral characteristics and MDD symptoms using a validated Patient Health Questionnaire-9 (PHQ-9) depression scale. Fasting blood glucose, insulin, C-reactive protein, and lipid concentrations were measured using standard approaches. Multivariate logistic regression models were fitted to estimate odds ratios (OR) and 95% confidence intervals (95% CI).

resultsA total of 154 participants screened positive for MDD on PHQ-9 (8.0%; 95% CI: 6.7-9.2%). Among women, MDD was associated with more than 4-fold increased odds of diabetes (OR=4.14; 95% CI: 1.03-16.62). Among men the association was not significant (OR=1.12; 95% CI: 0.63-1.99). Similarly, MDD was not associated with metabolic syndrome among women (OR=1.51; 95% CI: 0.69-3.29) and men (OR=0.61; 95% CI: 0.28-1.34). Lastly, MDD was not associated with increased odds of systemic inflammation.

conclusionThe results of our study do not provide convincing evidence that MDD is associated with cardiometabolic diseases among Ethiopian adults. Future studies need to evaluate the effect of other psychiatric disorders on cardiometabolic disease risk.

Indexed as

AdultBlood GlucoseC-Reactive ProteinDiabetes ComplicationsDiabetes MellitusEthiopiaFemaleHumansInsulinLipidsMajor Depressive DisorderMaleMetabolic SyndromeMultivariate AnalysisOdds RatioPrevalenceBlood GlucoseC-Reactive ProteinInsulinLipidsAfricaCardiovascular diseasesDepressionEthiopia

Identifiers

PMID25470634
PMCPMC4265581
OpenAlexW2054837952

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.