Enteroendocrine MC4R and energy balance: linking the long and the short of it.

Sean Manning, Rachel L Batterham

Open access · bronzeAbstract readComment

In one paragraph

Article in Cell metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it

0cells of the map it votes in

3citing papers in PubMed

1.2field-weighted citation impact, top 22% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 15 citations in OpenAlex.

Setmelanotide: A Melanocortin-4 Receptor Agonist for the Treatment of Severe Obesity Due to Hypothalamic Dysfunction.TouchREVIEWS in endocrinology · 2024
Review
Effects of Bacterial CLPB Protein Fragments on Food Intake and PYY Secretion.Nutrients · 2021
Article
Changes in Microbiota and Bacterial Protein Caseinolytic Peptidase B During Food Restriction in Mice: Relevance for the Onset and Perpetuation of Anorexia Nervosa.Nutrients · 2019
Article

4 · The record

Corrections and comments

Comment on
The melanocortin-4 receptor is expressed in enteroendocrine L cells and regulates the release of peptide YY and glucagon-like peptide 1 in vivo.2014

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Sean ManningCentre for Obesity Research, Rayne Institute, Department of Medicine, University College London, London WC1E 6JJ, UK; School of Medicine, University College Cork, Cork, Ireland.

Rachel L BatterhamCentre for Obesity Research, Rayne Institute, Department of Medicine, University College London, London WC1E 6JJ, UK; UCLH Centre for Weight Loss, Metabolic and Endocrine Surgery, University College London Hospitals, Ground Floor West Wing, 250 Euston Road, London NW1 2PG, UK; National Institute of Health Research University College London Hospitals Biomedical Research Centre, London W1T 7DN, UK. Electronic address: r.batterham@ucl.ac.uk.

University College Cork · IEUniversity College Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Central MC4R pathways are well established as integrators of peripheral signals in the control of energy balance. In this issue, Panaro et al. (2014) identify that MC4Rs expressed on intestinal enteroendocrine L cells regulate PYY and GLP-1 secretion, two gut hormones implicated in the regulation of energy and glucose homeostasis.

Indexed as

AnimalsEnteroendocrine CellsGlucagon-Like Peptide 1HumansPeptide YYReceptor, Melanocortin, Type 4Glucagon-Like Peptide 1Peptide YYReceptor, Melanocortin, Type 4

Identifiers

PMID25470541

DOI10.1016/j.cmet.2014.11.014

OpenAlexW1968590939

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.