Trial reportPloS one2014
Higher adenoma detection rates with endocuff-assisted colonoscopy - a randomized controlled multicenter trial.
Trial report in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 8 registered trials, which are not on this map. Cited by 48 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Controlled Study to Compare EndoCuff-assisted With Standard Colonoscopy for the Detection of Adenomas
Endocuff-assisted vs. Standard Colonoscopy: a Randomized, Back-to-Back Study
Endocuff-assisted vs. Standard Colonoscopy for Surveillance of Serrated Polyposis Syndrome: A Randomized Controlled Trial
Endocuff vs Transparent Cap To Increase Adenoma Detection Rate During Colonoscopy
A Prospective Randomized Comparison of the Adenoma Detection Rate in Screening Colonoscopy With and Without a Disposable Cap (ENDOCUFF VISION®)
Use of Endocuff Vision to Increase Detection of Sessile Serrated Adenomas During Screening Colonoscopy
Use of AmplifEYE-assisted Colonoscopy Compared to Standard Colonoscopy in Polyp and Adenoma Detection
Three Arm Prospective Randomized Controlled Trial of HD White-light Colonoscopy vs HD White-light Colonoscopy With Reveal® Distal Attachment Cap Versus HD White-light Colonoscopy With Endocuff Vision for the Detection of Colorectal Adenomas
Who cites it
48 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Adenoma and Advanced Adenoma Detection Rates of Water Exchange, Endocuff, and Cap Colonoscopy: A Network Meta-Analysis with Pooled Data of Randomized Controlled Trials.Digestive diseases and sciences · 2021Pooled it
- Effect of Endocuff use on colonoscopy outcomes: A systematic review and meta-analysis.World journal of gastroenterology · 2019Pooled it
- Use of the Endocuff during routine colonoscopy examination improves adenoma detection: A meta-analysis.World journal of gastroenterology · 2016Pooled it
- Texture and color enhancement imaging (TXI) plus endocuff vision versus TXI alone for colorectal adenoma detection: a randomized controlled trial.Surgical endoscopy · 2023Trial
- Standard versus Endocuff versus cap-assisted colonoscopy for adenoma detection: A randomised controlled clinical trial.United European gastroenterology journal · 2021Trial
- Trial
- Water Exchange Method Significantly Improves Adenoma Detection Rate: A Multicenter, Randomized Controlled Trial.The American journal of gastroenterology · 2017Trial
- Enhanced adenoma detection with Endocuff Vision: a GRADE assessed systematic review and meta-analysis.Clinical endoscopy · 2026Article
- Endocuff-Assisted Colonoscopy for Identifying Sessile Serrated Polyps and Adenomas During Routine Colorectal Cancer Screening: A Retrospective Cohort Study.JGH open : an open access journal of gastroenterology and hepatology · 2025Article
- Improvement in Adenoma Detection Rate with Distal Attachment Device Endo-Wing™-Assisted Colonoscopy: A Randomized Control Trial.Diagnostics (Basel, Switzerland) · 2025Article
- The impact of linked color imaging on adenoma detection rate in colonoscopy: a systematic review and meta-analysis.Clinical endoscopy · 2025Article
- Identification and validation of prognostic signature genes of bladder cancer by integrating methylation and transcriptomic analysis.Scientific reports · 2024Article
- Endocuff Vision-Assisted Resection for Difficult Colonic Lesions-Preliminary Results of a Multicenter, Prospective Randomized Pilot Study.Journal of clinical medicine · 2023Article
- Image enhanced colonoscopy: updates and prospects-a review.Translational gastroenterology and hepatology · 2023Review
- Detection of colorectal lesions during colonoscopy.DEN open · 2022Review
- Colorectal cancer screening and surveillance in patients with inflammatory bowel disease in 2021.World journal of gastroenterology · 2022Article
- Efficacy of Endocuff Vision compared to first-generation Endocuff in adenoma detection rate and polyp detection rate in high-definition colonoscopy: a systematic review and network meta-analysis.Endoscopy international open · 2021Review
- Number of significant polyps detected per six-minute withdrawal time at colonoscopy (SP6): a new measure of colonoscopy efficiency and quality.Frontline gastroenterology · 2020Article
- Frontiers of Robotic Colonoscopy: A Comprehensive Review of Robotic Colonoscopes and Technologies.Journal of clinical medicine · 2020Review
- Endocuff-Assisted versus Cap-Assisted Colonoscopy Performed by Trainees: A Retrospective Study.Clinical endoscopy · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe Endocuff is a device mounted on the tip of the colonoscope to help flatten the colonic folds during withdrawal. This study aimed to compare the adenoma detection rates between Endocuff-assisted (EC) colonoscopy and standard colonoscopy (SC).
methodsThis randomized prospective multicenter trial was conducted at four academic endoscopy units in Germany.
participants500 patients (235 males, median age 64[IQR 54-73]) for colon adenoma detection purposes were included in the study. All patients were either allocated to EC or SC. The primary outcome measure was the determination of the adenoma detection rates (ADR).
resultsThe ADR significantly increased with the use of the Endocuff compared to standard colonoscopy (35.4%[95% confidence interval{CI} 29-41%] vs. 20.7%[95%CI 15-26%], p<0.0001). Significantly more sessile polyps were detected by EC. Overall procedure time and withdrawal time did not differ. Caecal and ileum intubation rates were similar. No major adverse events occurred in both groups. In multivariate analysis, age (odds ratio [OR] 1.03; 95%[CI] 1.01-1.05), male sex (OR 1.74; 95%CI 1.10-2.73), withdrawal time (OR 1.16; 95%CI 1.05-1.30), procedure time (OR 1.07; 95%CI 1.04-1.10), colon cleanliness (OR 0.60; 95%CI 0.39-0.94) and use of Endocuff (OR 2.09; 95%CI 1.34-3.27) were independent predictors of adenoma detection rates.
conclusionsEC increases the adenoma detection rate by 14.7%(95%CI 6.9-22.5%). EC is safe, effective, easy to handle and might reduce colorectal interval carcinomas.
trial registrationClinicalTrials.gov NCT02034929.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.