Evidence map›Paper›PMID 25470103›Full record

ArticleThe Journal of clinical psychiatry2014

Dr. Mischoulon and colleagues reply.

David Mischoulon, Lawrence H Price, Linda L Carpenter, Audrey R Tyrka, George I Papakostas, Maurizio Fava

Registry-linked trialAbstract readLetterComment
PubMed Publisher
In one paragraph

Article in The Journal of clinical psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00101452 (A Double-Blind, Placebo-Controlled Study of the Alternative Therapy S-Adenosyl-L-Methionine), which is not on this map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00101452 nacompletednot on this map

A Double-Blind, Placebo-Controlled Study of the Alternative Therapy S-Adenosyl-L-Methionine (SAMe) vs Escitalopram in Major Depressive Disorder (MDD)

TypeinterventionalSponsorMaurizio Fava, MDRan2005 to 2010Enrolled199ConditionsDepressionArmsS-adenosyl-l-methionine, Escitalopram, Placebo
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. S-adenosyl methionine (SAMe) for depression in adults.The Cochrane database of systematic reviews · 2016
    Pooled it
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

David Mischoulondmischoulon@partners.org.
Lawrence H Price
Linda L Carpenter
Audrey R Tyrka
George I Papakostas
Maurizio Fava

Funding

Placebo-Controlled Study of SAMe vs.Escitalopram in MDDR01AT001638 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI FAVA, MAURIZIO · 2004 to 2008
$2.8M
Double-Blind study of SAMe vs Escitalopram in MDDR01AT001742 · NCCIH · BUTLER HOSPITAL (PROVIDENCE, RI) · PI PRICE, LAWRENCE H · 2004 to 2008
$1.0M
NCCIH NIH HHS R01AT001638NCCIH NIH HHS R01 AT001742
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antidepressive AgentsCitalopramFemaleHumansMajor Depressive DisorderMaleS-AdenosylmethionineSelective Serotonin Reuptake InhibitorsAntidepressive AgentsCitalopramS-AdenosylmethionineSelective Serotonin Reuptake Inhibitors

Identifiers

PMID25470103

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.