ReviewCurrent opinion in nephrology and hypertension2015
Obesity and kidney disease: differential effects of obesity on adipose tissue and kidney inflammation and fibrosis.
Review in Current opinion in nephrology and hypertension, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.
- Effects of Bariatric Surgery on Renal Function in Obese Patients: A Systematic Review and Meta Analysis.PloS one · 2016Pooled it
- Irisin-Driven AMPK-PGC-1α Activation Underlies the Renoprotective Effects of Swimming Exercise in Obesity-Induced Kidney Injury.Biomolecules · 2026Article
- Sex-specific association of visceral adiposity index with renal dysfunction in chinese type 2 diabetes: A cross-sectional study.PloS one · 2026Article
- Platelet-to-high-density lipoprotein cholesterol ratio as a potential mediator in the obesity-chronic kidney disease association among hypertensive patients.Renal failure · 2025Article
- Exercise-mediated amelioration of high-fat diet-induced kidney injury: implications of microRNA regulation.Renal failure · 2025Article
- The effects of time-restricted feeding on early vascular, liver, and renal structural changes, oxidative stress, and inflammation in obese rats.Scientific reports · 2025Article
- Obesity-Related Glomerulosclerosis-How Adiposity Damages the Kidneys.International journal of molecular sciences · 2025Review
- Maternal obesity promotes impaired renal autophagic process and kidney injury in male offspring.International journal of obesity (2005) · 2025Article
- The Role of Mitochondrial AKT1 Signaling in Renal Tubular Injury of Metabolic Syndrome.Kidney international reports · 2025Article
- Association between the ratio of triglyceride to high-density lipoprotein cholesterol (TG/HDL-c) and chronic kidney disease risk: a large-scale cross-sectional study in a Chinese population.Frontiers in medicine · 2025Article
- Metabolic Syndrome, Kidney-Related Adiposity, and Kidney Microcirculation: Unraveling the Damage.Biomedicines · 2024Review
- Hypertension and diabetes, but not leptin and adiponectin, mediate the relationship between body fat and chronic kidney disease.Endocrine · 2024Article
- Article
- Effects of bariatric surgery on renal function: a retrospective cohort study comparing one-year outcomes between one-anastomosis gastric bypass and Roux-en-Y gastric bypass.Sao Paulo medical journal = Revista paulista de medicina · 2024Observational
- Potential of bone morphogenetic protein-7 in treatment of lupus nephritis: addressing the hurdles to implementation.Inflammopharmacology · 2023Review
- Review
- Therapeutic Effects of Bee Bread on Obesity-Induced Testicular-Derived Oxidative Stress, Inflammation, and Apoptosis in High-Fat Diet Obese Rat Model.Antioxidants (Basel, Switzerland) · 2022Article
- Kidney Damage Caused by Obesity and Its Feasible Treatment Drugs.International journal of molecular sciences · 2022Review
- The association between obesity and vitamin D deficiency modifies the progression of kidney disease after ischemia/reperfusion injury.Frontiers in nutrition · 2022Article
- Metabolomics Provides Insights into Renoprotective Effects of Semaglutide in Obese Mice.Drug design, development and therapy · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
purpose of reviewTo provide a perspective by investigating the potential cross-talk between the adipose tissue and the kidney during obesity. RECENT
findingsIt is well established that excessive caloric intake contributes to organ injury. The associated increased adiposity initiates a cascade of cellular events that leads to progressive obesity-associated diseases such as kidney disease. Recent evidence has indicated that adipose tissue produces bioactive substances that contribute to obesity-related kidney disease, altering the renal function and structure. In parallel, proinflammatory processes within the adipose tissue can also lead to pathophysiological changes in the kidney during the obese state. SUMMARY: Despite considerable efforts to better characterize the pathophysiology of obesity-related metabolic disease, there are still a lack of efficient therapeutic strategies. New strategies focused on regulating adipose function with respect to AMP-activated protein kinase activation, NADPH oxidase function, and TGF-β may contribute to reducing adipose inflammation that may also provide renoprotection.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.