Evidence map›Paper›PMID 25469998›Full record

ReviewObesity (Silver Spring, Md.)2015

NIH working group report: Innovative research to improve maintenance of weight loss.

Paul S MacLean, Rena R Wing, Terry Davidson, Leonard Epstein, Bret Goodpaster, Kevin D Hall, Barry E Levin, Michael G Perri, Barbara J Rolls, Michael Rosenbaum and 2 more

Abstract readConsensus Development Conference, NIHReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Obesity (Silver Spring, Md.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 279 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
279citing papers in PubMed, 15 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

279 citing papers in PubMed, 15 syntheses or guidelines pooled it.

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  8. Obesity in South and Southeast Asia-A new consensus on care and management.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2023
    Guideline
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  13. Successful weight loss maintenance: A systematic review of weight control registries.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2020
    Pooled it
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  15. Treatment of adolescent obesity.Nature reviews. Endocrinology · 2018
    Pooled it
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219 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Paul S MacLeanDepartment of Medicine, Division of Endocrinology, Metabolism, and Diabetes, University of Colorado School of Medicine, Aurora, Colorado, USA.
Rena R Wing
Terry Davidson
Leonard Epstein
Bret Goodpaster
Kevin D Hall
Barry E Levin
Michael G Perri
Barbara J Rolls
Michael Rosenbaum
Alexander J Rothman
Donna Ryan

Funding

PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Wendy M Kohrt · 1995 to 2026
$32.6M
University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI CHRISTIAAN LEEUWENBURGH · 2007 to 2026
$22.8M
Sex Hormones Differentially Regulate Production of Distinct Adipocyte PopulationP50HD073063 · NICHD · UNIVERSITY OF COLORADO DENVER · PI KOHRT, WENDY M · 2012 to 2017
$5.7M
Computational modeling of human metabolism, body weight and compositionZIADK013036 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI HALL, KEVIN · 2009 to 2024
$3.6M
A Narrowed Window for Targeting Metabolic Flexibility in Breast Cancer PreventionR01CA164166 · NCI · UNIVERSITY OF COLORADO DENVER · PI MACLEAN, PAUL S., SCHEDIN, PEPPER J · 2013 to 2017
$1.6M
NCI NIH HHS R01 CA164166NIA NIH HHS P30 AG028740NICHD NIH HHS P50 HD073063NIDDK NIH HHS P30 DK048520
6 · The paper itself

Abstract

objectivesThe National Institutes of Health, led by the National Heart, Lung, and Blood Institute, organized a working group of experts to discuss the problem of weight regain after weight loss. A number of experts in integrative physiology and behavioral psychology were convened with the goal of merging their perspectives regarding the barriers to scientific progress and the development of novel ways to improve long-term outcomes in obesity therapeutics. The specific objectives of this working group were to: (1) identify the challenges that make maintaining a reduced weight so difficult; (2) review strategies that have been used to improve success in previous studies; and (3) recommend novel solutions that could be examined in future studies of long-term weight control.

resultsSpecific barriers to successful weight loss maintenance include poor adherence to behavioral regimens and physiological adaptations that promote weight regain. A better understanding of how these behavioral and physiological barriers are related, how they vary between individuals, and how they can be overcome will lead to the development of novel strategies with improved outcomes.

conclusionsGreater collaboration and cross-talk between physiological and behavioral researchers is needed to advance the science and develop better strategies for weight loss maintenance.

Indexed as

Biomedical ResearchWeight LossBody WeightHealth BehaviorHumansNational Institutes of Health (U.S.)ObesityPatient ComplianceResearch ReportTherapies, InvestigationalUnited States

Identifiers

PMID25469998
PMCPMC5841916

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.