Evidence map›Paper›PMID 25469926›Full record

ArticleMolecular psychiatry2015

Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study.

D J Gottlieb, K Hek, T-H Chen, N F Watson, G Eiriksdottir, E M Byrne, M Cornelis, S C Warby, S Bandinelli, L Cherkas and 76 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 10 syntheses or guidelines pooled it.

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11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

86 authors.

D J GottliebVA Boston Healthcare System, Boston, MA, USA.
K HekDepartment of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.
T-H ChenVA Boston Healthcare System, Boston, MA, USA.
N F WatsonDepartment of Neurology, University of Washington, Seattle, WA, USA.
G EiriksdottirIcelandic Heart Association, Kópavogur, Iceland.
E M ByrneThe University of Queensland, Queensland Brain Institute, St Lucia, QLD, Australia.
M CornelisDepartment of Nutrition, Harvard School of Public Health, Boston, MA, USA.
S C WarbyCenter for Sleep Sciences and Medicine, Stanford University, Palo Alto, CA, USA.
S BandinelliGeriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy.
L CherkasDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
D S EvansCalifornia Pacific Medical Center Research Institute, San Francisco, CA, USA.
H J GrabeDepartment of Psychiatry and Psychotherapy, HELIOS-Hospital Stralsund, University Medicine Greifswald, Greifswald, Germany.
J LahtiInstitute of Behavioural Sciences, University of Helsinki, Helsinki, Finland.
M LiDepartment of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
T LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories and School of Medicine, University of Tampere, Tampere, Finland.
T LumleyDepartment of Statistics, University of Auckland, Auckland, New Zealand.
K D MarcianteDepartment of Medicine, University of Washington, Seattle, WA, USA.
L PérusseDepartment of Kinesiology, Laval University, Quebec, Canada.
B M PsatyDepartment of Medicine, University of Washington, Seattle, WA, USA.
J RobbinsDepartment of Internal Medicine, University of California Davis, Sacramento, CA, USA.
G J TranahCalifornia Pacific Medical Center Research Institute, San Francisco, CA, USA.
J M VinkDepartment of Biological Psychology, Netherlands Twin Register, VU University, Amsterdam, The Netherlands.
J B WilkPrecision Medicine, Cambridge, MA, USA.
J M StaffordDivision of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
C BellisTexas Biomedical Research Institute, San Antonio, TX, USA.
R BiffarDepartment of Prosthodontics, Gerodontology and Dental Materials, Center of Oral Health, University Medicine Greifswald, Greifswald, Germany.
C BouchardPennington Biomedical Research Center, Baton Rouge, LA, USA.
B CadeDivision of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
G C CurhanChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
J G ErikssonFolkhalsan Research Centre, Helsinki, Finland.
R EwertDepartment of Internal Medicine B-Cardiology, Pulmonary Medicine, Infectious Diseases and Intensive Care Medicine, University Medicine Greifswald, Greifswald, Germany.
L FerrucciTranslational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.
T FülöpDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.
P R GehrmanDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
R GoodloeCenter for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN, USA.
T B HarrisLaboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD, USA.
A C HeathDepartment of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
D HernandezLaboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA.
A HofmanEpidemiological and Social Psychiatric Research Institute, Department of Psychiatry, Erasmus MC, Rotterdam, The Netherlands.
J-J HottengaDepartment of Biological Psychology, Netherlands Twin Register, VU University, Amsterdam, The Netherlands.
D J HunterDepartment of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
M K JensenDepartment of Nutrition, Harvard School of Public Health, Boston, MA, USA.
A D JohnsonNHLBI Cardiovascular Epidemiology and Human Genomics Branch, The Framingham Heart Study, Framingham, MA, USA.
M KähönenDepartment of Clinical Physiology, Tampere University Hospital and School of Medicine University of Tampere, Tampere, Finland.
L KaoDepartment of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
P KraftDepartment of Epidemiology, Harvard School of Public Health, Boston, MA, USA.
E K LarkinDepartment of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA.
D S LauderdaleDepartment of Health Studies, University of Chicago, Chicago, IL, USA.
A I LuikEpidemiological and Social Psychiatric Research Institute, Department of Psychiatry, Erasmus MC, Rotterdam, The Netherlands.
M MediciDepartment of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands.
G W MontgomeryQueensland Institute of Medical Research, Brisbane, QLD, Australia.
A PalotieInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
S R PatelDivision of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
G PistisDivision of Genetics and Cell Biology, San Raffaele Research Institute, Milano, Italy.
E PorcuIstituto di Ricerca Genetica e Biomedica (IRGB), Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari, Italy.
L QuayeDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
O RaitakariResearch Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, and Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.
S RedlineDivision of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
E B RimmDepartment of Nutrition, Harvard School of Public Health, Boston, MA, USA.
J I RotterInstitute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA.
A V SmithIcelandic Heart Association, Kópavogur, Iceland.
T D SpectorDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
A TeumerInterfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
A G UitterlindenEpidemiological and Social Psychiatric Research Institute, Department of Psychiatry, Erasmus MC, Rotterdam, The Netherlands.
M-C VohlInstitute of Nutrition and Functional Foods, Laval University, Quebec, Canada.
E WidenInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
G WillemsenDepartment of Biological Psychology, Netherlands Twin Register, VU University, Amsterdam, The Netherlands.
T YoungDepartment of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA.
X ZhangNHLBI Cardiovascular Epidemiology and Human Genomics Branch, The Framingham Heart Study, Framingham, MA, USA.
Y LiuDivision of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC, USA.
J BlangeroTexas Biomedical Research Institute, San Antonio, TX, USA.
D I BoomsmaDepartment of Biological Psychology, Netherlands Twin Register, VU University, Amsterdam, The Netherlands.
V GudnasonIcelandic Heart Association, Kópavogur, Iceland.
F HuDepartment of Nutrition, Harvard School of Public Health, Boston, MA, USA.
M ManginoDepartment of Twin Research and Genetic Epidemiology, King's College London, London, UK.
N G MartinQueensland Institute of Medical Research, Brisbane, QLD, Australia.
G T O'ConnorDepartment of Medicine, Boston University School of Medicine, Boston, MA, USA.
K L StoneCalifornia Pacific Medical Center Research Institute, San Francisco, CA, USA.
T TanakaTranslational Gerontology Branch, National Institute on Aging, Baltimore, MD, USA.
J ViikariDepartment of Medicine, Turku University Hospital and University of Turku, Turku, Finland.
S A GharibUW Medicine Sleep Center, University of Washington, Seattle, WA, USA.
N M PunjabiDepartment of Epidemiology, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, USA.
K RäikkönenInstitute of Behavioural Sciences, University of Helsinki, Helsinki, Finland.
H VölzkeInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.
E MignotCenter for Sleep Sciences and Medicine, Stanford University, Palo Alto, CA, USA.
H TiemeierDepartment of Epidemiology, Erasmus MC, Rotterdam, The Netherlands.

Funding

NIMH Center Repository Supporting Stem Cell ResearchU24MH068457 · NIMH · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI BRZUSTOWICZ, LINDA M, KNOWLES, JAMES A · 2003 to 2024
$213.8M
Statistical MethodsP01CA087969 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI TWOROGER, SHELLEY S · 2000 to 2019
$77.8M
Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
OREGON CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024140 · NCRR · OREGON HEALTH & SCIENCE UNIVERSITY · PI ORWOLL, ERIC S. · 2006 to 2011
$61.1M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Validity of Diet and Activity Measures in WomenP01CA055075 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI WILLETT, WALTER C. · 1991 to 2009
$41.8M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4M
INSTITUTIONAL CTSA (UW-MADISON): CLINICAL TRIALSUL1RR025011 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2007 to 2011
$29.5M
Cardiovascular Genomics and Bioinformatics projectsZIAHL006170 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI JOHNSON, ANDREW · 2013 to 2025
$25.3M
Study of Osteoporotic FracturesR01AG005407 · NIA · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI CUMMINGS, STEVEN RON, YAFFE, KRISTINE · 1986 to 2016
$23.2M
Genome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2M
SPECTRUM OF NARCOLEPSY AND ITS SYMPTOMSP50NS023724 · NINDS · STANFORD UNIVERSITY · PI MIGNOT, EMMANUEL J · 1986 to 2016
$18.9M
CCR NIH HHS RC2ARO58973CIHR FRN-CCT-83028Intramural NIH HHSNCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1TR000124NCI NIH HHS CA055075NCI NIH HHS CA087969NCI NIH HHS CA40356NCI NIH HHS CA98233NCI NIH HHS P01 CA055075NCI NIH HHS P01 CA087969NCI NIH HHS R01 CA040356NCI NIH HHS R35 CA197449NCI NIH HHS U01 CA098233NCRR NIH HHS 1UL1RR025011NCRR NIH HHS UL1 RR024140NCRR NIH HHS UL1 RR025005NCRR NIH HHS UL1RR025005NCRR NIH HHS UL1 RR025011NCRR NIH HHS UL1 RR033176NCRR NIH HHS UL1RR033176NHGRI NIH HHS HG004399NHGRI NIH HHS HHSN268200782096CNHGRI NIH HHS U01 HG004399NHGRI NIH HHS U01 HG004402NHGRI NIH HHS U01HG004402NHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HL080295NHLBI NIH HHS HL087652NHLBI NIH HHS HL105756NHLBI NIH HHS HL35464NHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC055015NHLBI NIH HHS N01 HC055016NHLBI NIH HHS N01 HC055018NHLBI NIH HHS N01 HC055019NHLBI NIH HHS N01 HC055020NHLBI NIH HHS N01 HC055021NHLBI NIH HHS N01 HC055022NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01‐HC‐25195NHLBI NIH HHS N01-HC-55015NHLBI NIH HHS N01-HC-55016NHLBI NIH HHS N01-HC-55018NHLBI NIH HHS N01-HC-55019NHLBI NIH HHS N01-HC-55020NHLBI NIH HHS N01-HC-55021NHLBI NIH HHS N01-HC-55022NHLBI NIH HHS N01-HC-55222NHLBI NIH HHS N01-HC-85079NHLBI NIH HHS N01-HC-85080NHLBI NIH HHS N01-HC-85081NHLBI NIH HHS N01-HC-85082NHLBI NIH HHS N01-HC-85083NHLBI NIH HHS N01-HC-85086NHLBI NIH HHS N01-HC-85239NHLBI NIH HHS N02‐HL‐6‐4278NHLBI NIH HHS R01 HL035464NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL062252NHLBI NIH HHS R01 HL070837NHLBI NIH HHS R01 HL070838NHLBI NIH HHS R01 HL070839NHLBI NIH HHS R01 HL070841NHLBI NIH HHS R01 HL070842NHLBI NIH HHS R01 HL070847NHLBI NIH HHS R01 HL070848NHLBI NIH HHS R01 HL071194NHLBI NIH HHS R01 HL080295NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01HL087641NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL113338NHLBI NIH HHS R01HL59367NHLBI NIH HHS R01HL62252NHLBI NIH HHS U01 HL080295NIAAA NIH HHS AA11998NIAAA NIH HHS AA13320NIAAA NIH HHS AA13321NIAAA NIH HHS AA13326NIAAA NIH HHS AA14041NIAAA NIH HHS P50 AA011998NIAAA NIH HHS R01 AA007535NIAAA NIH HHS R01 AA010249NIAAA NIH HHS R01 AA013320NIAAA NIH HHS R01 AA013321NIAAA NIH HHS R01 AA013326NIAAA NIH HHS R01 AA014041NIAMS NIH HHS R01 AR035582NIAMS NIH HHS R01 AR035583NIAMS NIH HHS R01 AR035584NIAMS NIH HHS R01 AR35582NIAMS NIH HHS R01 AR35583NIAMS NIH HHS R01 AR35584NIAMS NIH HHS RC2 AR058973NIAMS NIH HHS U01 AR045580NIAMS NIH HHS U01 AR045583NIAMS NIH HHS U01 AR045614NIAMS NIH HHS U01 AR045632NIAMS NIH HHS U01 AR045647NIAMS NIH HHS U01 AR045654NIAMS NIH HHS U01 AR066160NIAMS NIH HHS U01 AR45580NIAMS NIH HHS U01 AR45583NIAMS NIH HHS U01 AR45614NIAMS NIH HHS U01 AR45632NIAMS NIH HHS U01 AR45647NIAMS NIH HHS U01 AR45654NIA NIH HHS 1R01AG030474-01A1NIA NIH HHS 1R01AG032098-01A1NIA NIH HHS AG023629NIA NIH HHS N01 AG062101NIA NIH HHS N01 AG062103NIA NIH HHS N01 AG062106NIA NIH HHS N01-AG-62101NIA NIH HHS N01-AG-62103NIA NIH HHS N01-AG-62106NIA NIH HHS R01 AG005394NIA NIH HHS R01 AG005407NIA NIH HHS R01 AG023629NIA NIH HHS R01 AG026720NIA NIH HHS R01 AG027574NIA NIH HHS R01AG027574NIA NIH HHS R01 AG027576NIA NIH HHS R01 AG030474NIA NIH HHS R01 AG032098NIA NIH HHS R56 AG023629NIA NIH HHS U01 AG018197NIA NIH HHS U01 AG027810NIA NIH HHS U01-AG027810NIA NIH HHS U01 AG18197NICHD NIH HHS U54 HD083211NIDDK NIH HHS DK058845NIDDK NIH HHS DK063491NIDDK NIH HHS DK070756NIDDK NIH HHS P01 DK070756NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK058845NIMHD NIH HHS R01 MD009164NIMH NIH HHS 1RC2MH089951-01NIMH NIH HHS 1RC2 MH089995-01NIMH NIH HHS MH66206NIMH NIH HHS R01 MH066206NIMH NIH HHS RC2 MH089951NIMH NIH HHS RC2 MH089995NIMH NIH HHS U24 MH068457NIMH NIH HHS U24 MH068457-06NINDS NIH HHS NS23724NINDS NIH HHS P50 NS023724PHS HHS R01D0042157-01AWellcome Trust 079771Wellcome Trust 099194Wellcome Trust WT089062
6 · The paper itself

Abstract

Usual sleep duration is a heritable trait correlated with psychiatric morbidity, cardiometabolic disease and mortality, although little is known about the genetic variants influencing this trait. A genome-wide association study (GWAS) of usual sleep duration was conducted using 18 population-based cohorts totaling 47 180 individuals of European ancestry. Genome-wide significant association was identified at two loci. The strongest is located on chromosome 2, in an intergenic region 35- to 80-kb upstream from the thyroid-specific transcription factor PAX8 (lowest P=1.1 × 10(-9)). This finding was replicated in an African-American sample of 4771 individuals (lowest P=9.3 × 10(-4)). The strongest combined association was at rs1823125 (P=1.5 × 10(-10), minor allele frequency 0.26 in the discovery sample, 0.12 in the replication sample), with each copy of the minor allele associated with a sleep duration 3.1 min longer per night. The alleles associated with longer sleep duration were associated in previous GWAS with a more favorable metabolic profile and a lower risk of attention deficit hyperactivity disorder. Understanding the mechanisms underlying these associations may help elucidate biological mechanisms influencing sleep duration and its association with psychiatric, metabolic and cardiovascular disease.

Indexed as

AdultAgedBlack or African AmericanDyssomniasFemaleGenetic Association StudiesGenome-Wide Association StudyHumansMaleMiddle AgedPolymorphism, Single NucleotideSelf ReportSleepWhite People

Identifiers

PMID25469926
PMCPMC4430294

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