Optimizing membrane-protein biogenesis through nonoptimal-codon usage.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

9 citing papers in PubMed.

1. Comparative Analysis of Codon Usage Patterns and Host Adaptation inViruses · 2025
   Article
2. Codon Bias Can Determine Sorting of a Potassium Channel Protein.Cells · 2021
   Article
3. Deciphering the co-adaptation of codon usage between respiratory coronaviruses and their human host uncovers candidate therapeutics for COVID-19.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2020
   Article
4. Correcting the F508del-CFTR variant by modulating eukaryotic translation initiation factor 3-mediated translation initiation.The Journal of biological chemistry · 2018
   Article
5. Evolutionary analysis of polyproline motifs in Escherichia coli reveals their regulatory role in translation.PLoS computational biology · 2018
   Article
6. Predicting synonymous codon usage and optimizing the heterologous gene for expression in E. coli.Scientific reports · 2017
   Article
7. On the Spatial Organization of mRNA, Plasmids, and Ribosomes in a Bacterial Host Overexpressing Membrane Proteins.PLoS genetics · 2016
   Article
8. Ribosomal Stalk Protein Silencing Partially Corrects the ΔF508-CFTR Functional Expression Defect.PLoS biology · 2016
   Article
9. Optimizing assembly and production of native bispecific antibodies by codon de-optimization.mAbs
   Article

Corrections and comments

• Comment on
  Local slowdown of translation by nonoptimal codons promotes nascent-chain recognition by SRP in vivo.2014

Authors and funding

2 authors.

Funding

Abstract

PubMed holds no abstract for this paper.

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