ArticleCancer2015
Racial/ethnic disparities in inflammatory gene single-nucleotide polymorphisms as predictors of a high risk for symptom burden in patients with multiple myeloma 1 year after diagnosis.
Article in Cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- A systematic review of the association between fatigue and genetic polymorphisms.Brain, behavior, and immunity · 2017Pooled it
- Minocycline for symptom reduction during radiation therapy for head and neck cancer: a randomized clinical trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020Trial
- Translational genomic research: the role of genetic polymorphisms in MBSR program among breast cancer survivors (MBSR[BC]).Translational behavioral medicine · 2019Trial
- Fatigue in hematological cancer changes across chemotherapy trajectory within the context of IL-6, not hemoglobin level: evidence from growth curve modeling.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Observational
- Article
- Cancer-related cognitive impairment is associated with perturbations in inflammatory pathways.Cytokine · 2021Article
- Metabolic Disorders in Multiple Myeloma.International journal of molecular sciences · 2021Review
- A biocultural approach to psychiatric illnesses.Psychopharmacology · 2019Review
- Protein Cytokines, Cytokine Gene Polymorphisms, and Potential Acute Coronary Syndrome Symptoms.Biological research for nursing · 2019Article
- Understanding Symptom Burden in Patients With Advanced Cancer Living in Rural Areas.Oncology nursing forum · 2019Article
- Expression and clinical significance of SLP-2 in ovarian tumors.Oncology letters · 2019Article
- Biomarkers as Common Data Elements for Symptom and Self-Management Science.Journal of nursing scholarship : an official publication of Sigma Theta Tau International Honor Society of Nursing · 2018Article
- Advancing Symptom Science Through Symptom Cluster Research: Expert Panel Proceedings and Recommendations.Journal of the National Cancer Institute · 2017Review
- Article
- Translating Hispanic Genomic Factors in Lung Cancer Into Clinical Practice: EGFR Testing for Improved Outcomes.Gene, cell and tissue · 2016Article
- Distribution of cytokine gene single nucleotide polymorphisms among a multi-ethnic Iranian population.Advanced biomedical research · 2015Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThis study was conducted to determine whether any regulatory single-nucleotide polymorphism (SNP) in an inflammatory gene was associated with a high symptom burden in patients 1 year after the diagnosis of multiple myeloma (MM).
methodsMM patients rated symptoms with the MD Anderson Symptom Inventory multiple myeloma module (MDASI-MM) and provided buccal-swab DNA samples. SNPs for 4 cytokine genes (interleukin 6 [IL6] -174G>C, IL1β -511C>T, tumor necrosis factor α [TNFα] -308G>A, and IL10 -1082G>A) were tested. Logistic regression models were used to identify SNPs that might predict moderate/severe symptoms (rated ≥ 4 on the MDASI-MM 0-10 scale). For the evaluation of the relationship between SNPs and overall symptom burden, a 2-step cluster analysis was used to divide patients into subgroups with high or low symptom levels.
resultsForty-one percent of the 344 patients enrolled had a high overall symptom burden. The most prevalent moderate/severe symptoms were fatigue (47%), pain (42%), numbness (38%), and bone aches (32%). For non-Hispanic whites, the IL1β -511 CC genotype was associated with a high overall symptom burden (odds ratio [OR], 2.35; 95% confidence interval [CI], 1.25-4.72; P = .004), whereas the IL6 -174 GG genotype predicted less moderate/severe fatigue (OR, 0.53; 95% CI, 0.29-0.88; P = .013). For other patients, the IL6 -174 GG genotype predicted moderate/severe pain (OR, 3.36; 95% CI, 1.23-13.64; P = .010).
conclusionsThese results support growing evidence showing that inflammation is associated with cancer-related symptoms, and they suggest that racial/ethnic factors contribute to this association.
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