Evidence map›Paper›PMID 25469807›Full record

ReviewJournal of cardiovascular pharmacology2015

Role of peripheral vascular resistance for the association between major depression and cardiovascular disease.

Elena V Bouzinova, Ove Wiborg, Christian Aalkjaer, Vladimir V Matchkov

Open access · hybridAbstract readReview
In one paragraph

Review in Journal of cardiovascular pharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Resting beat-to-beat blood pressure variability is preserved in young adults with major depressive disorder.American journal of physiology. Regulatory, integrative and comparative physiology · 2025
    Article
  3. Article
  4. Article
  5. Antidepressant Drugs Effects on Blood Pressure.Frontiers in cardiovascular medicine · 2021
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Elena V Bouzinova*Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; †Department of Biomedicine, MEMBRANES, Aarhus University, Aarhus, Denmark; and ‡Department of Biomedicine, Copenhagen University, Copenhagen, Denmark.
Ove Wiborg
Christian Aalkjaer
Vladimir V Matchkov
Aarhus University · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Major depression and cardiovascular diseases are 2 of the most prevalent health problems in Western society, and an association between them is generally accepted. Although the specific mechanism behind this comorbidity remains to be elucidated, it is clear that it has a complex multifactorial character including a number of neuronal, humoral, immune, and circulatory pathways. Depression-associated cardiovascular abnormalities associate with cardiac dysfunctions and with changes in peripheral resistance. Although cardiac dysfunction in association with depression has been studied in detail, little attention was given to structural and functional changes in resistance arteries responsible for blood pressure control and tissue perfusion. This review discusses recent achievements in studies of depression-associated abnormalities in resistance arteries in humans and animal experimental models. The changes in arterial structure, contractile and relaxing functions associated with depression symptoms are discussed, and the role of these abnormalities for the pathology of major depression and cardiovascular diseases are suggested.

Indexed as

Cardiovascular DiseasesMajor Depressive DisorderAnimalsBlood VesselsComorbidityHumansVascular Resistance

Identifiers

PMID25469807
PMCPMC4415957
OpenAlexW1978163509

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.