ArticlePsychosomatic medicine2015
Psychosocial stress as a risk factor for sepsis: a population-based cohort study.
Article in Psychosomatic medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Gender differences in depression in representative national samples: Meta-analyses of diagnoses and symptoms.Psychological bulletin · 2017Pooled it
- Community-onset sepsis and its public health burden: a systematic review.Systematic reviews · 2016Pooled it
- Causal associations between severe mental illness and sepsis: a Mendelian randomization study.Frontiers in psychiatry · 2024Article
- Outcomes of Acute Pancreatitis in Hospitalized Patients With Generalized Anxiety Disorder.Cureus · 2023Article
- Prior exposure to stress exacerbates neuroinflammation and causes long-term behavior changes in sepsis.Heliyon · 2023Article
- Feasibility and Challenges with Measuring Adverse Childhood Experiences in the Pediatric Intensive Care Unit.Journal of child & adolescent trauma · 2023Article
- Urban-Rural Disparities in Case Fatality of Community-Acquired Sepsis in Germany: A Retrospective Cohort Study.International journal of environmental research and public health · 2023Article
- Genetic predispositions to psychiatric disorders and the risk of COVID-19.BMC medicine · 2022Article
- The Relationship between Stress, Inflammation, and Depression.Biomedicines · 2022Review
- Perceived stress in Chinese patients with coronary heart disease: a cross-sectional study.BMJ open · 2022Article
- Longitudinal association between mental health and future antibiotic prescriptions in healthy adults: Results from the LOHAS.PloS one · 2020Article
- Analysis of Occupational Stress and Its Relationship with Secretory Immunoglobulin A in the Xinjiang Plateau Young Military Recruits.BioMed research international · 2020Article
- Stress related disorders and subsequent risk of life threatening infections: population based sibling controlled cohort study.BMJ (Clinical research ed.) · 2019Article
- The Role of Inflammation in Depression and Fatigue.Frontiers in immunology · 2019Review
- Psychoneuroimmunology-developments in stress research.Wiener medizinische Wochenschrift (1946) · 2018Review
- Psychological distress and salivary secretory immunity.Brain, behavior, and immunity · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo characterize the relationship between stress and future risk of sepsis. We also evaluated the role of depression in this relationship.
methodsWe used population-based data on 30,183 participants in the Reasons for Geographic and Racial Differences in Stroke cohort, characterizing stress using the Perceived Stress Scale (PSS) and depressive symptoms using the Center for Epidemiologic Studies Depression Scale (CES-D). We identified incident sepsis events as hospitalizations for a serious infection with the presence of at least two systemic inflammatory response syndrome criteria. We assessed associations between PSS and incidence of sepsis for 1 and 10 years of follow-up, adjusting for demographics and chronic medical conditions and assessing the role of health behaviors and CES-D in these relationships.
resultsIn 2003 to 2012, 1500 participants experienced an episode of sepsis. Mean PSS and CES-D scores were 3.2 (2.9) and 1.2 (2.1). PSS was associated with increased 1-year adjusted incidence of sepsis (hazard ratio [HR] = 1.21 per PSS standard deviation, 95% confidence interval = 1.06-1.38); multivariable adjustment for health behaviors and CES-D did not change this association (1.20, 1.03-1.39). PSS was also associated with increased 10-year adjusted incidence of sepsis (HR = 1.07 per PSS standard deviation; 95% confidence interval = 1.02-1.13). Multivariable adjustment showed that health behaviors did not affect this long-term association, whereas the addition of CES-D reduced the association between PSS and sepsis during 10-year follow-up (HR = 1.04, 0.98-1.11).
conclusionsIncreased stress was associated with higher 1-year adjusted incidence of sepsis, even after accounting for depressive symptoms. The association between stress and 10-year adjusted incidence of sepsis was also significant, but this association was reduced when adjusting for depressive symptoms. Reduction of stress may limit short-term sepsis risk.
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