ReviewAdvances in nutrition (Bethesda, Md.)2014
Hypercholesterolemia induces adipose dysfunction in conditions of obesity and nonobesity.
Review in Advances in nutrition (Bethesda, Md.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 61 citations in OpenAlex.
- Adipokines and Vascular Modulators in CKM: Emerging Biomarkers as Diagnostic and Therapeutic Targets.International journal of molecular sciences · 2025Review
- Neuropsychiatric Abnormalities in Metabolic Disturbances: Interplay of Adipokines and Neurotransmission.Molecular neurobiology · 2025Review
- Article
- Demographics, Comorbidities, and Care-Seeking Intent Among Individuals with Obesity or Overweight Status Using Outpatient AI-Based Virtual Triage.Telemedicine reports · 2025Article
- Obesity, dyslipidemia, and cardiovascular disease: A joint expert review from the Obesity Medicine Association and the National Lipid Association 2024.Obesity pillars · 2024Article
- Electroacupuncture regulates hepatic cholesterol synthesis by HMGCR deubiquitination in rats.Heliyon · 2023Article
- Cyclodextrin-Mediated Cholesterol Depletion Induces Adiponectin Secretion in 3T3-L1 Adipocytes.International journal of molecular sciences · 2023Article
- Plasticity of adipose tissues in response to fasting and refeeding declines with aging in mice.Aging · 2023Article
- Effect ofJournal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2023Review
- Wax apple (Journal of traditional and complementary medicine · 2022Article
- Network analysis of atherosclerotic genes elucidates druggable targets.BMC medical genomics · 2022Article
- Association of 3-hydroxy-3-methylglutaryl-coenzyme A reductase gene polymorphism with obesity and lipid metabolism in children and adolescents with autism spectrum disorder.Metabolic brain disease · 2022Article
- Adipokine Retinol Binding Protein 4 and Cardiovascular Diseases.Frontiers in physiology · 2022Review
- Adipose tissue macrophages and atherogenesis - a synergy with cholesterolaemia.Physiological research · 2021Review
- Article
- Associations of GDF-15 and GDF-15/adiponectin ratio with odds of type 2 diabetes in the Chinese population.Endocrine · 2021Article
- High fat high sucrose diet-induced dyslipidemia in guinea pigs.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
- Article
- Pro- and Anti-inflammatory Effects of High Cholesterol Diet on Aged Brain.Aging and disease · 2018Article
- Targeted Deletion of Adipocyte Abca1 (ATP-Binding Cassette Transporter A1) Impairs Diet-Induced Obesity.Arteriosclerosis, thrombosis, and vascular biology · 2018Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is well known that hypercholesterolemia can lead to atherosclerosis and coronary heart disease. Adipose tissue represents an active endocrine and metabolic site, which might be involved in the development of chronic disease. Because adipose tissue is a key site for cholesterol metabolism and the presence of hypercholesterolemia has been shown to induce adipocyte cholesterol overload, it is critical to investigate the role of hypercholesterolemia on normal adipose function. Studies in preadipocytes revealed that cholesterol accumulation can impair adipocyte differentiation and maturation by affecting multiple transcription factors. Hypercholesterolemia has been observed to cause adipocyte hypertrophy, adipose tissue inflammation, and disruption of endocrine function in animal studies. Moreover, these effects can also be observed in obesity-independent conditions as confirmed by clinical trials. In humans, hypercholesterolemia disrupts adipose hormone secretion of visfatin, leptin, and adiponectin, adipokines that play a central role in numerous metabolic pathways and regulate basic physiologic responses such as appetite and satiety. Remarkably, treatment with cholesterol-lowering drugs has been shown to restore adipose tissue endocrine function. In this review the role of hypercholesterolemia on adipose tissue differentiation and maturation, as well as on hormone secretion and physiologic outcomes, in obesity and non–obesity conditions is presented.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.