ArticleF1000Research2014
[18F]-T807 tauopathy PET imaging in chronic traumatic encephalopathy.
Article in F1000Research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 32 citations in OpenAlex.
- Chronic traumatic encephalopathy in athletes, players, boxers and military: systematic review.Annals of medicine and surgery (2012) · 2024Review
- Assessing Mild Traumatic Brain Injury-Associated Blood-Brain Barrier (BBB) Damage and Restoration Using Late-Phase Perfusion Analysis by 3D ASL MRI: Implications for Predicting Progressive Brain Injury in a Focused Review.International journal of molecular sciences · 2024Review
- A critical review of radiotracers in the positron emission tomography imaging of traumatic brain injury: FDG, tau, and amyloid imaging in mild traumatic brain injury and chronic traumatic encephalopathy.European journal of nuclear medicine and molecular imaging · 2021Review
- Emerging advances of in vivo detection of chronic traumatic encephalopathy and traumatic brain injury.The British journal of radiology · 2019Review
- The Value of In Vitro Binding as Predictor of In Vivo Results: A Case for [Molecular imaging and biology · 2019Article
- Pathological correlations of [F-18]-AV-1451 imaging in non-alzheimer tauopathies.Annals of neurology · 2017Article
- Injury cascades in TBI-related neurodegeneration.Brain injury · 2017Review
- Cerebral [Translational psychiatry · 2016Article
- Characteristics of Tau and Its Ligands in PET Imaging.Biomolecules · 2016Review
- Preliminary Study of Plasma Exosomal Tau as a Potential Biomarker for Chronic Traumatic Encephalopathy.Journal of Alzheimer's disease : JAD · 2016Article
- Chronic traumatic encephalopathy and athletes.Neurology · 2015Review
- A review of neuroimaging findings in repetitive brain trauma.Brain pathology (Zurich, Switzerland) · 2015Review
- The Quest to Model Chronic Traumatic Encephalopathy: A Multiple Model and Injury Paradigm Experience.Frontiers in neurology · 2015Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A new molecular ligand for positron emission tomography (PET) of the human brain, [18F]-T807, is under investigation for the antemortem detection of pathological neurofibrillary aggregates, which are evidence of neurofibrillary tangle (NFT) diseases, also known as tauopathies. Repetitive mild traumatic brain injuries in athletes and battlefield veterans are associated with one such tauopathy, known as chronic traumatic encephalopathy (CTE). In a recent case report, a former NFL player with clinically probable CTE and a concurrent Progressive Supranuclear Palsy (PSP) -like syndrome was studied using [18F]-T807. The interpretation of this player's [18F]-T807 PET imaging was complicated by the overlap of tracer uptake in brain regions involved in CTE and PSP with regions associated with either nonspecific [18F]-T807 ligand binding or "aging-associated" binding of [18F]-T807 to authentic tauopathy known to be associated with aging and disease severity (i.e., NFT in the mesial temporal lobe). The implications of these data for the utility of [18F]-T807 in the pre-mortem detection of CTE are summarized.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.