ArticleEvolutionary applications2014
Environmental dependency of amphibian-ranavirus genotypic interactions: evolutionary perspectives on infectious diseases.
Article in Evolutionary applications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Experimental evidence for behavioural cooling as a response to virus infection in an ectothermic vertebrate.BMC biology · 2026Article
- A Conceptual Disease Cycle Model to Link the Size of Past and Future Epidemics.Ecology and evolution · 2025Review
- Seasonality Has Greater Influence on Amphibian Cutaneous Mycobiome than Host Species.Journal of fungi (Basel, Switzerland) · 2025Article
- Article
- Heat stress and amphibian immunity in a time of climate change.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Host traits and environment interact to determine persistence of bat populations impacted by white-nose syndrome.Ecology letters · 2022Article
- Ranavirus Amplification in Low-Diversity Amphibian Communities.Frontiers in veterinary science · 2022Article
- Patterns of infection, origins, and transmission of ranaviruses among the ectothermic vertebrates of Asia.Ecology and evolution · 2021Review
- Host-multiparasite interactions in amphibians: a review.Parasites & vectors · 2021Review
- Ambient temperature alters body size and gut microbiota of Xenopus tropicalis.Science China. Life sciences · 2020Article
- Behavioural fever reduces ranaviral infection in toads.Functional ecology · 2019Article
- eDNA Increases the Detectability of Ranavirus Infection in an Alpine Amphibian Population.Viruses · 2019Article
- Functional variation at an expressed MHC class IIβ locus associates with Ranavirus infection intensity in larval anuran populations.Immunogenetics · 2019Article
- Seasonal dynamics and potential drivers of ranavirus epidemics in wood frog populations.Oecologia · 2018Article
- Article
- Ranavirus genotypes in the Netherlands and their potential association with virulence in water frogs (Pelophylax spp.).Emerging microbes & infections · 2018Article
- Article
- Cryptic chytridiomycosis linked to climate and genetic variation in amphibian populations of the southeastern United States.PloS one · 2017Article
- The role of evolutionary biology in research and control of liver flukes in Southeast Asia.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2016Review
- Water Temperature Affects Susceptibility to Ranavirus.EcoHealth · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The context-dependent investigations of host-pathogen genotypic interactions, where environmental factors are explicitly incorporated, allow the assessment of both coevolutionary history and contemporary ecological influences. Such a functional explanatory framework is particularly valuable for describing mortality trends and identifying drivers of disease risk more accurately. Using two common North American frog species (Lithobates pipiens and Lithobates sylvaticus) and three strains of frog virus 3 (FV3) at different temperatures, we conducted a laboratory experiment to investigate the influence of host species/genotype, ranavirus strains, temperature, and their interactions, in determining mortality and infection patterns. Our results revealed variability in host susceptibility and strain infectivity along with significant host-strain interactions, indicating that the outcome of an infection is dependent on the specific combination of host and virus genotypes. Moreover, we observed a strong influence of temperature on infection and mortality probabilities, revealing the potential for genotype-genotype-environment interactions to be responsible for unexpected mortality in this system. Our study thus suggests that amphibian hosts and ranavirus strains genetic characteristics should be considered in order to understand infection outcomes and that the investigation of coevolutionary mechanisms within a context-dependent framework provides a tool for the comprehensive understanding of disease dynamics.
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