Evidence map›Paper›PMID 25469136›Full record

ArticleIranian journal of reproductive medicine2014

Estradiol progesterone ratio on ovulation induction day: a determinant of successful pregnancy outcome after intra cytoplasmic sperm injection.

Rehana Rehman, Rakhshaan Khan, Mukhtiar Baig, Mehwish Hussain, Syeda Sadia Fatima

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Article in Iranian journal of reproductive medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Rehana RehmanBahria University Medical and Dental College, Karachi, Pakistan.
Rakhshaan KhanDepartment of Biological and Biomedical Sciences, Faculty of Health Sciences, Medical College, The Aga Khan University, Karachi, Pakistan.
Mukhtiar BaigFaculty of Medicine, Rabigh, King Abdulaziz University, Jeddah, KSA.
Mehwish HussainResearch Development, Dow University of Health Sciences, Karachi, Pakistan.
Syeda Sadia FatimaDepartment of Biological and Biomedical Sciences, Faculty of Health Sciences, Medical College, The Aga Khan University, Karachi, Pakistan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntracytoplasmic sperm injection (ICSI) is an advanced technique employed in assisted reproductive clinics for treatment of infertile couples. The reproductive endocrinologists try their level best to identify factors that enhance success rate after ICSI.

objectiveTo compare estradiol progesterone ratio on ovulation induction day amongst pregnancy outcome groups following ICSI. MATERIALS AND

methodsA cross sectional study was conducted on 323 couples of Assisted Reproductive Clinic in Islamabad from June 2010 till August 2011. Down regulation of females aged 18-40 years with gonadotrophin releasing hormone agonist was followed by calculated stimulation with gonadotrophin injections (COS). Oocytes pickup was done 36 hours after ovulation induction by 16G adapter and double lumen oocyte aspiration needle under general anesthesia. Oocytes were fertilized in vitro, graded and only blastocysts were transferred seven days after ovulation induction. Serum estradiol and progesterone were measured by enzyme linked immuno sorbent assay on ovulation induction day, ratio was compared in three groups of females; no conception with βhCG 5-25 mIU/ml, preclinical abortion with βhCG >25 mIU/ml and no cardiac activity on transvaginal scan and clinical pregnancy with βhCG >25mIU/ml and cardiac activity on transvaginal scan.

resultsFemales having high estradiol/ progesterone ratio were able to achieve clinical pregnancy shown by a positive βhCG and cardiac activity on transvaginal scan. These females also had significantly high number of oocytes, endometrial thickness and implantation rate.

conclusionA high estradiol/progesterone ratio on the day of ovulation induction predicts the success of intra cytoplasmic sperm injection.

Indexed as

ImplantaionIntracytoplasmic sperm injectionOvulation inductionPregnancy outcome

Identifiers

PMID25469136
PMCPMC4248148

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