ArticleIranian journal of reproductive medicine2014
Culturing surplus poor-quality embryos to blastocyst stage have positive predictive value of clinical pregnancy rate.
Article in Iranian journal of reproductive medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Potential of growth factors and steroid hormones from cell cultures to improveOpen veterinary journal · 2025Review
- The impact of different ovarian stimulation protocols on the expression levels of GDF-9 and BMP-15 in cumulus cells of follicles.Frontiers in endocrinology · 2025Article
- Development speed of sibling embryo positively reflects live birth rate after fresh day 3 embryo transfer.Scientific reports · 2023Article
- Assuring quality in assisted reproduction laboratories: assessing the performance of ART Compass - a digital art staff management platform.Journal of assisted reproduction and genetics · 2023Article
- Improving the clinical outcomes by extended culture of day 3 embryos with low blastomere number to blastocyst stage following frozen-thawed embryo transfer.Archives of gynecology and obstetrics · 2021Article
- Reproductive outcomes of 3 infertile males with XYY syndrome: Retrospective case series and literature review.Medicine · 2020Review
- Use of two new formulations as bovine embryo manipulation solution.Animal reproduction · 2019Article
- Improves the In Vitro Developmental Competence and Reprogramming Efficiency of Cloned Bovine Embryos by Additional Complimentary Cytoplasm.Cellular reprogramming · 2019Article
- Intracytoplasmic sperm injection outcome of ejaculated spermatozoa from a man with mosaic Klinefelter's Syndrome: case report and literature review.The Journal of international medical research · 2018Review
- What we learned from extended culture of 'rejected' day-3 cleavage stage embryos: a prospective cohort study.Journal of ovarian research · 2017Article
- Effect of sperm DNA fragmentation on clinical outcomes for Chinese couples undergoing in vitro fertilization or intracytoplasmic sperm injection.The Journal of international medical research · 2016Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundClinical reproductive centers produce large amounts of surplus poor-quality embryos annually, how to maximize the use of these embryos, and which of them have the potential to develop into blastocyst stage and influencing factors were lack of systematic research.
objectiveTo investigate the fate of surplus poor-quality embryos which were cultured to obtain blastocyst, determine the factors which may influence the blastulation, and discuss their application in predicting of the pregnancy outcomes. MATERIALS AND
methodsDay 3 (D3) after embryo transfer and freezing, surplus poor-quality embryos from IVF/ICSI cycles were cultured to blastocyst by the sequential method, then the blastulation outcomes were observed. Focusing on the blastulation rate of those embryos with different number cells and different embryonic grade; and last the relationship between the pregnancy outcomes of remained poor-quality embryos with successful blastulation or failed blastulation groups were studied.
resultsOf 127 patients with 569 poor-quality in vitro cultured embryos, there were formation of 248 blastocysts from 91 patients (43.59%), which lead to development of 138 high-quality blastocysts (24.25%). With the increase in cells number of D 3 blastomeres, the blastulation rate gradually increased, that, 7-cell blastomeres blastulation rate was the highest (70.59%), and 8-cell blastomeres is a little below (70.37%); while the embryonic levels and blastulation rate did not show this positive relationship. The clinical pregnancy rate and implantation rate of those who had successful blastulation (67.03% and 42.39%) were higher than of those who failed to develop to blastocyst (p=0.039).
conclusionDay 3 poor-quality embryos with successful blastulation or with failed blastulation had predictive value on pregnancy outcomes. For embryo transfer 7-8 cells grade III-IV embryo is better than 4-5 cells grade I-II embryo, in case of lack good-quality embryos.
Indexed as
Identifiers
25469133PMC4248145What OpenQuestion holds
Registered trials
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