ArticleIranian journal of reproductive medicine2014
Effect of vitamin D insufficiency treatment on fertility outcomes in frozen-thawed embryo transfer cycles: A randomized clinical trial.
Article in Iranian journal of reproductive medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 7 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Beyond the Umbrella: A Systematic Review of the Interventions for the Prevention of and Reduction in the Incidence and Severity of Ovarian Hyperstimulation Syndrome in Patients Who Undergo In Vitro Fertilization Treatments.International journal of molecular sciences · 2023Pooled it
- Influence of Vitamin D supplementation on reproductive outcomes of infertile patients: a systematic review and meta-analysis.Reproductive biology and endocrinology : RB&E · 2023Pooled it
- Effects of vitamin D supplementation in endometriosis: a systematic review.Reproductive biology and endocrinology : RB&E · 2022Pooled it
- Effect of Vitamin D Supplementation onFrontiers in endocrinology · 2022Pooled it
- Preconception lifestyle advice for people with infertility.The Cochrane database of systematic reviews · 2021Pooled it
- Antioxidants for female subfertility.The Cochrane database of systematic reviews · 2020Pooled it
- Antioxidants for female subfertility.The Cochrane database of systematic reviews · 2017Pooled it
- Efficacy and safety of nutritional supplements in female infertility: a network meta-analysis.Reproductive biology and endocrinology : RB&E · 2025Review
- Vitamin D in Reproductive Health Disorders: A Narrative Review Focusing on Infertility, Endometriosis, and Polycystic Ovarian Syndrome.International journal of molecular sciences · 2025Review
- Supplementation with vitamin D improves the embryo quality in in vitro fertilization (IVF) programs, independently of the patients' basal vitamin D status.Archives of gynecology and obstetrics · 2024Article
- Chromosome ends and the theory of marginotomy: implications for reproduction.Biogerontology · 2024Review
- Impact of thyroid autoimmunity and vitamin D onFrontiers in endocrinology · 2023Article
- Dietary supplementation for female infertility: Recent advances in the nutritional therapy for premature ovarian insufficiency.Frontiers in microbiology · 2022Review
- Female infertility and diet, is there a role for a personalized nutritional approach in assisted reproductive technologies? A Narrative Review.Frontiers in nutrition · 2022Review
- Article
- Review
- Is there any association between vitamin D levels and polycystic ovary syndrome (PCOS) phenotypes?Archives of endocrinology and metabolism · 2020Article
- Effect of vitamin D supplementation on assisted reproduction technology (ART) outcomes and underlying biological mechanisms: protocol of a randomized clinical controlled trial. The "supplementation of vitamin D and reproductive outcome" (SUNDRO) study.BMC pregnancy and childbirth · 2019Article
- Review
- Effect of Vitamin D Supplementation on Intracytoplasmic Sperm Injection Outcomes: A Randomized Double-Blind Placebo-Controlled Trial.International journal of fertility & sterility · 2019Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFrozen- thawed embryo transfer is an essential part of ART treatment and outcomes of this procedure are associated with several clinical factors. Several studies have showed an increase level of IVF outcomes in women with sufficient vitamin D.
objectivewhether treatment of vitamin D insufficiency can improve pregnancy rates in frozen-thawed embryo transfer cycles. MATERIALS AND
methodsThis is an interventional, randomized clinical trial. Serum 25-(OH) vitamin D level of 128 women who had undergone IVF/ICSI with cryopreservation of embryos was checked. One hundred fourteen infertile women with insufficient serum vitamin D (less than 30 ng/ml) were included in the study. Fifty seven women were treated with supplementary vitamin D, 50000 IU weekly, for 6-8 weeks and fifty seven women were received no supplementation. One hundred six women completed frozen thawed embryo transfer cycles and included in the final analysis. Primary and secondary outcomes were chemical and clinical pregnancy respectively.
resultsOur study did not show any significant difference between vitamin D insufficient and treated women in term of chemical (29.40% vs. 29.10% respectively, p=1.00) or clinical (25.50% vs. 21.80% respectively, p=0.81) pregnancy rates.
conclusionVitamin D insufficiency treatment is not associated with higher pregnancy rate in frozen-thawed embryo transfer cycles.
Indexed as
Identifiers
25469131PMC4248143W2202314899What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.