Evidence map›Paper›PMID 25469075›Full record

ArticleJournal of Korean medical science2014

The value of SPECT/CT in localizing pain site and prediction of treatment response in patients with chronic low back pain.

Inki Lee, Hendra Budiawan, Jee Youn Moon, Gi Jeong Cheon, Yong Chul Kim, Jin Chul Paeng, Keon Wook Kang, June-Key Chung, Dong Soo Lee

Open access · goldAbstract read
In one paragraph

Article in Journal of Korean medical science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Effectiveness of single-photon emission computed tomography (SPECT/SPECT-CT) in predicting therapeutic response to facet interventions for facet joint-related low back pain: A systematic review and Meta-Analysis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025
    Pooled it
  2. Efficacy and safety of [European journal of nuclear medicine and molecular imaging · 2026
    Trial
  3. Article
  4. Article
  5. SPECT/CT Scan: A New Diagnostic Tool in Pain Medicine.Current pain and headache reports · 2023
    Review
  6. Review
  7. Review
  8. Article
  9. Bone SPECT/CT in the postoperative spine: a focus on spinal fusion.European journal of nuclear medicine and molecular imaging · 2017
    Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Inki LeeDepartment of Nuclear Medicine, Seoul National University Hospital, Seoul, Korea.ORCID 0000-0002-2051-3597
Hendra BudiawanDepartment of Nuclear Medicine, Seoul National University Hospital, Seoul, Korea. ; Fellowship of Koh Chang Soon Program, Seoul National University College of Medicine, Seoul, Korea. ; Department of Nuclear Medicine, MochtarRiady Comprehensive Cancer Centre - Siloam Hospitals Semanggi, Jakarta, Indonesia.ORCID 0000-0002-8645-5916
Jee Youn MoonDepartment of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul, Korea.ORCID 0000-0001-5551-7750
Gi Jeong CheonDepartment of Nuclear Medicine, Seoul National University Hospital, Seoul, Korea. ; Cancer Research Institute, Seoul National University, Seoul, Korea.ORCID 0000-0002-1360-5186
Yong Chul KimDepartment of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul, Korea.ORCID 0000-0002-8461-5322
Jin Chul PaengDepartment of Nuclear Medicine, Seoul National University Hospital, Seoul, Korea.ORCID 0000-0002-7464-9342
Keon Wook KangDepartment of Nuclear Medicine, Seoul National University Hospital, Seoul, Korea. ; Cancer Research Institute, Seoul National University, Seoul, Korea.ORCID 0000-0003-2622-9017
June-Key ChungDepartment of Nuclear Medicine, Seoul National University Hospital, Seoul, Korea. ; Cancer Research Institute, Seoul National University, Seoul, Korea.ORCID 0000-0002-6866-8571
Dong Soo LeeDepartment of Nuclear Medicine, Seoul National University Hospital, Seoul, Korea.ORCID 0000-0001-9013-4835
Seoul National University Hospital · KRSeoul National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In many circumstances, causing sites of low back pain (LBP) cannot be determined only by anatomical imaging. Combined functional and morphological imaging such as bone scan with single-photon emission computed tomography/computed tomography (SPECT/CT) may be helpful in identifying active lesions. The purpose of this study was to evaluate the usefulness of bone SPECT/CT in localizing the pain site and the treatment of chronic LBP. One hundred seventy-five patients suffering from chronic LBP who underwent SPECT/CT were included, retrospectively. All of the patients received multiple general treatments according to the symptoms, and some of them underwent additional target-specific treatment based on SPECT/CT. Numerical rating scale (NRS) pain score was used to assess the pain intensity. Of 175 patients, 127 showed good response to the given therapies, while the rest did not. Overall, 79.4% of patients with definite active lesions showed good response. Patients with mild active or no lesions on SPECT/CT had relatively lower response rate of 63.0%. Good response was observed by the treatment with the guidance of active lesions identified on SPECT/CT. SPECT/CT could be useful in identifying active lesions in patients with chronic LBP and guiding the clinicians to use adequate treatment.

Indexed as

AdolescentAdultAgedAged, 80 and overChronic PainFemaleHumansLow Back PainLumbar VertebraeMaleMiddle AgedMultimodal ImagingPain MeasurementReproducibility of ResultsRetrospective StudiesSensitivity and SpecificityLow Back PainPain ManagementTechnetium-99m (Tc-99m), Methylene Diphosphonate (MDP)Tomography, Emission-Computed, Single-PhotonTomography, X-Ray Computed

Identifiers

PMID25469075
PMCPMC4248596
OpenAlexW2156510631

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.