ArticleWorld journal of gastroenterology2014
Hepatic clearance measured with (99m)Tc-GSA single-photon emission computed tomography to estimate liver fibrosis.
Article in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Development and validation of a nomogram model for predicting acute hepatic dysfunction post-intervention in primary hepatocellular carcinoma: a retrospective case-control study.World journal of surgical oncology · 2025Article
- Blood-pool SUV analysis of 99mTc-galactosyl human serum albumin (99mTc-GSA) normalized by blood volume for prediction of short-term survival in severe liver failure: preliminary report.Annals of nuclear medicine · 2025Article
- Assessing Liver Function in Rat Models of Acute Liver Failure Using Single-Photon Emission Computed Tomography and Cytokine Levels.PloS one · 2025Article
- Remnant liver function is associated with long-term survival in patients with hepatocellular carcinoma undergoing hepatectomy.Scientific reports · 2023Article
- Clearance of the liver remnant predicts short-term outcome in patients undergoing resection of hepatocellular carcinoma.World journal of gastroenterology · 2022Review
- Indocyanine green plasma clearance rate and 99mTc-galactosyl human serum albumin single-photon emission computed tomography evaluated preoperative remnant liver.World journal of clinical cases · 2022Article
- Liver Fibrosis Conventional and Molecular Imaging Diagnosis Update.Journal of liver · 2019Article
- Desmin- and vimentin-mediated hepatic stellate cell-targeting radiotracerTheranostics · 2018Article
- Potential application of neogalactosylalbumin in positron emission tomography evaluation of liver function.World journal of gastroenterology · 2017Article
- Ceruloplasmin, a reliable marker of fibrosis in chronic hepatitis B virus patients with normal or minimally raised alanine aminotransferase.World journal of gastroenterology · 2016Article
- Development of a Protocol for Dynamic Gastric Emptying Scintigraphy.In vivo (Athens, Greece)Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate the clinical utility of hepatic clearance (HC) measured with technetium-99m-diethylenetriaminepenta-acetic acid-galactosyl human serum albumin ((99m)Tc-GSA) single-photon emission computed tomography (SPECT) to estimate the degree of liver fibrosis.
methodsSeventy-eight consecutive patients who underwent initial hepatectomy due to hepatocellular carcinoma were enrolled in this study. Indocyanine green clearance (ICG R15), quantitative indices estimated by (99m)Tc-GSA [the receptor index (LHL15 and HH15) and HC via SPECT analysis], and conventional liver function tests were performed before hepatectomy. Correlations among the quantitative indices for liver functional reserve, conventional liver function tests, and the degree of liver fibrosis were evaluated.
resultsThe degree of liver fibrosis was correlated with ICG R15, HH15, LHL15, and HC. HC showed the best correlation with conventional liver function tests. According to multivariate analysis, HC and LHL15 were significant independent predictors of severe fibrosis. HC was the most valuable index for predicting severe fibrosis.
conclusionHC measured with (99m)Tc-GSA SPECT is a reliable index for assessing liver fibrosis before hepatectomy.
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