Evidence map›Paper›PMID 25469037›Full record

ArticleWorld journal of gastroenterology2014

Azathioprine does not reduce adenoma formation in a mouse model of sporadic intestinal tumorigenesis.

Mattheus C B Wielenga, Jooske F van Lidth de Jeude, Sanne L Rosekrans, Alon D Levin, Monique Schukking, Geert R A M D'Haens, Jarom Heijmans, Marnix Jansen, Vanesa Muncan, Gijs R van den Brink

Open access · hybridAbstract read
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In one paragraph

Article in World journal of gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Mattheus C B WielengaMattheus CB Wielenga, Jooske F van Lidth de Jeude, Sanne L Rosekrans, Alon D Levin, Monique Schukking, Geert RAM D'Haens, Jarom Heijmans, Vanesa Muncan, Gijs R van den Brink, Tytgat Institute for Liver and Intestinal Research and Department of Gastroenterology and Hepatology, Academic Medical Center, 1105BK Amsterdam, The Netherlands.
Jooske F van Lidth de JeudeMattheus CB Wielenga, Jooske F van Lidth de Jeude, Sanne L Rosekrans, Alon D Levin, Monique Schukking, Geert RAM D'Haens, Jarom Heijmans, Vanesa Muncan, Gijs R van den Brink, Tytgat Institute for Liver and Intestinal Research and Department of Gastroenterology and Hepatology, Academic Medical Center, 1105BK Amsterdam, The Netherlands.
Sanne L RosekransMattheus CB Wielenga, Jooske F van Lidth de Jeude, Sanne L Rosekrans, Alon D Levin, Monique Schukking, Geert RAM D'Haens, Jarom Heijmans, Vanesa Muncan, Gijs R van den Brink, Tytgat Institute for Liver and Intestinal Research and Department of Gastroenterology and Hepatology, Academic Medical Center, 1105BK Amsterdam, The Netherlands.
Alon D LevinMattheus CB Wielenga, Jooske F van Lidth de Jeude, Sanne L Rosekrans, Alon D Levin, Monique Schukking, Geert RAM D'Haens, Jarom Heijmans, Vanesa Muncan, Gijs R van den Brink, Tytgat Institute for Liver and Intestinal Research and Department of Gastroenterology and Hepatology, Academic Medical Center, 1105BK Amsterdam, The Netherlands.
Monique SchukkingMattheus CB Wielenga, Jooske F van Lidth de Jeude, Sanne L Rosekrans, Alon D Levin, Monique Schukking, Geert RAM D'Haens, Jarom Heijmans, Vanesa Muncan, Gijs R van den Brink, Tytgat Institute for Liver and Intestinal Research and Department of Gastroenterology and Hepatology, Academic Medical Center, 1105BK Amsterdam, The Netherlands.
Geert R A M D'HaensMattheus CB Wielenga, Jooske F van Lidth de Jeude, Sanne L Rosekrans, Alon D Levin, Monique Schukking, Geert RAM D'Haens, Jarom Heijmans, Vanesa Muncan, Gijs R van den Brink, Tytgat Institute for Liver and Intestinal Research and Department of Gastroenterology and Hepatology, Academic Medical Center, 1105BK Amsterdam, The Netherlands.
Jarom HeijmansMattheus CB Wielenga, Jooske F van Lidth de Jeude, Sanne L Rosekrans, Alon D Levin, Monique Schukking, Geert RAM D'Haens, Jarom Heijmans, Vanesa Muncan, Gijs R van den Brink, Tytgat Institute for Liver and Intestinal Research and Department of Gastroenterology and Hepatology, Academic Medical Center, 1105BK Amsterdam, The Netherlands.
Marnix JansenMattheus CB Wielenga, Jooske F van Lidth de Jeude, Sanne L Rosekrans, Alon D Levin, Monique Schukking, Geert RAM D'Haens, Jarom Heijmans, Vanesa Muncan, Gijs R van den Brink, Tytgat Institute for Liver and Intestinal Research and Department of Gastroenterology and Hepatology, Academic Medical Center, 1105BK Amsterdam, The Netherlands.
Vanesa MuncanMattheus CB Wielenga, Jooske F van Lidth de Jeude, Sanne L Rosekrans, Alon D Levin, Monique Schukking, Geert RAM D'Haens, Jarom Heijmans, Vanesa Muncan, Gijs R van den Brink, Tytgat Institute for Liver and Intestinal Research and Department of Gastroenterology and Hepatology, Academic Medical Center, 1105BK Amsterdam, The Netherlands.
Gijs R van den BrinkMattheus CB Wielenga, Jooske F van Lidth de Jeude, Sanne L Rosekrans, Alon D Levin, Monique Schukking, Geert RAM D'Haens, Jarom Heijmans, Vanesa Muncan, Gijs R van den Brink, Tytgat Institute for Liver and Intestinal Research and Department of Gastroenterology and Hepatology, Academic Medical Center, 1105BK Amsterdam, The Netherlands.
Academic Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate if azathioprine could reduce adenoma formation in Apc(Min/+) , a mouse model of sporadic intestinal tumorigenesis.

methodsAzathioprine was administered via drinking water (estimated 6-20 mg/kg body weight per day) to Apc(Min/+) and wildtype mice. Control animals received vehicle only (DMSO) dissolved in drinking water. At 15 wk of age all mice were sacrificed and intestines of Apc(Min/+) were harvested for evaluation of polyp number. Azathioprine induced toxicity was investigated by immunohistochemical analysis on spleens.

resultsAll azathioprine treated mice showed signs of drug-associated toxicity such as weight loss and development of splenic T-cell lymphomas. Although this suggests that the thiopurine concentration was clearly in the therapeutic range, it did not reduce tumor formation (48 ± 3.1 adenomas vs 59 ± 5.7 adenomas, P = 0.148).

conclusionWe conclude that in the absence of inflammation, azathioprine does not affect intestinal tumorigenesis.

Indexed as

Adenomatous Polyposis ColiAnimalsAnticarcinogenic AgentsAzathioprineFemaleGenes, APCLymphoma, T-CellMaleMice, Inbred C57BLMice, TransgenicSplenic NeoplasmsTime FactorsAnticarcinogenic AgentsAzathioprineApcMinAzathioprineChemopreventionColon cancerIntestinal adenomaLymphomaPolypThiopurine

Identifiers

PMID25469037
PMCPMC4248212
OpenAlexW2089283231

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.